ALS (Lou Gehrig's Disease)

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. ALS is often called Lou Gehrig's disease, after the famous baseball player who was diagnosed with it in the 1930s.

The ALS Association

The ALS Association site offers a clear lay-language description of the disease, referral information for local chapters and support groups, and a description of publications that may be ordered from the Association.

NINDS Amyotrophic Lateral Sclerosis Information Page

The National Institute of Neurological Disorders and Stroke's Amyotrophic Lateral Sclerosis page provides scientific, but accessible, material on the ALS prognosis and treatment options, along with links to current research studies and other organizations.

The Muscular Dystrophy Association

The Muscular Dystrophy Association focuses its mission on more than 40 neuromuscular diseases, including ALS. Its site includes an online version of The ALS Newsletter, medical information about ALS and other neuromuscular diseases, and clinical trial links.

Dana Articles

Genetics and ALS: Cause for Optimism

By: Roland Pochet, Ph.D.

While drug development has done little to slow the devastating symptoms of amyotrophic lateral sclerosis (ALS), there is some good news in the fact that scientists have identified some 100 related genes and believe that genetic research offers the best hope for treatments.

ALS: A Mystery Almost Solved?

Scientists seem to be zeroing in on the once-elusive mechanisms of ALS, and are starting to design and test therapies that target those mechanisms.

Have Researchers Discovered the Key to ALS?

Lost function of ALS-linked protein TDP-43 seen as potentially major contributor to disease. 

Taking Out The Garbage: New Hope for Treating Neurodegeneration

Dementias, ALS, and Huntington’s show different outward symptoms, but researchers theorize the disease process may be similar—a buildup of proteins that normally are cleared away.

For ALS, Clues in Different Directions

Symptoms of the disease follow the deaths of motor neurons, but ALS’s ultimate cause may lie elsewhere.

Stem Cell Model Offers a New Target in ALS

A compound built from skin cells of people with an inherited form of the disease appears to stem the growth of mutant proteins.