Lack of interest or pleasure in daily activities, sadness and feelings of worthlessness or excessive guilt that are severe enough to interfere with working, sleeping, studying, eating and enjoying life.

Brain & Behavior Research Foundation

The Brain & Behavior Research Foundation’s site answers frequently asked questions about mental illnesses, including depression, and discusses research advances in treating and understanding these illnesses.

Depression and Bipolar Support Alliance

Depression and Bipolar Support Alliance's easy-to-use Web site offers helpful information about mood disorders, support groups, the Association's programs and publications. The site also provides links and resources for further information.

MedLine Plus: Depression

This easy-to-use service of the National Library of Medicine and the National Institutes of Health provides links to articles, pamphlets, and organizations relating to depression.

Mental Health America: Depression

Mental Health America, formerly the National Mental Health Association, provides information about many forms of mental illness (including depression), treatment options, and medication resources. In addition, free brochures and reports are available.

National Alliance on Mental Illness

The National Alliance on Mental Illness Web site houses resources on a host of mental illnesses, such as depression, obsessive-compulsive disorder, and borderline personality disorder. The site also provides information on treatments, support groups, and recovery from mental illness.

NIMH: Depression

This National Institute of Mental Health page provides information about the symptoms, treatments, and current research on depression, in addition to links to relevant publications and information on how to get help.

Dana Articles

Neuroimaging Advances for Depression

By:  Boadie W. Dunlop, M.D., and Helen S. Mayberg, M.D.

(Listen to Q&A with Helen S. Mayberg, M.D.)
While neuroimaging for depression have made strides in recent years, no findings have been sufficiently replicated or considered significant enough to warrant application in clinical settings. Our authors tell us what the future may bring.

Lithium to the Rescue

By: Richard S. Jope, Ph.D., and Charles B. Nemeroff, M.D., Ph.D.

(Read Q&A with Richard S. Jope, Ph.D.)
The element lithium is given in capsule form as a mood stabilizer for bipolar disorder and depression. New research, however, reveals its role as a neuroprotector, and suggests that enzymes modulated by lithium could lead to new treatments for Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and other neurodegenerative disorders.

Depression: Treatment Beyond Medication

The American College of Physicians has issued a new clinical practice guideline suggesting that cognitive behavioral therapy (CBT) is an equally viable choice to treat adults with depression.

The Search for the Signature of Depression

Using longitudinal studies of families and brain imaging of children, researchers find potential biomarkers of risk.

Holiday Blues: Getting the Facts, Forgetting the Myth

 Statistics refute a common myth that suicides increase during the winter holidays, but that doesn’t mean that holiday depression or sadness isn’t real for some people. Experts weigh in on what factors may contribute to these “holiday blues” and offer ways to cope with stress.


The Evolving State of Electroconvulsive Therapy

As doctors continue to tweak using electricity as therapy, a new meta-analysis suggests quicker application may be nearly as effective and has much less risk of side effects.