Wednesday, January 07, 2015

Appraising the Risks of Reefer Madness

By: Sir Robin Murray, M.D.

Editor’s Note: Studies that have tied cannabis use to schizophrenia in the developing brain are just the tip of the iceberg when it comes to marijuana. Are different strains and synthetic cannabinoids especially dangerous? Are we doing enough to educate young people on the risks? Does marijuana use lower IQ? Where is the line between medical marijuana and recreational use? Our author, a noted British psychiatrist, offers a European perspective on these issues

Cerebrum - January 2015 - article - feature
credit/source: Shutterstock

 
Beginning in the mid-1980s, European psychiatrists like me started seeing an increasing number of previously well-functioning teenagers who had developed hallucinations and delusions: the characteristic picture of schizophrenia. These troubled patients puzzled us because most had been bright and sociable and had no ties to the usual risk factors such as a family history of the disorder or developmental insult to the brain. Family and friends would often say, “Maybe it was all the cannabis they have been smoking,” and we would confidently reassure them that they were mistaken and tell them that cannabis was known to be a safe drug.

My view began to shift when a colleague, Peter Allebeck from the Karolinska Institute in Stockholm, launched his own investigation. He had been struck similarly by seeing well-adjusted young people develop schizophrenia for no apparent reason. The wonderful Swedish national records system enabled him to trace the outcome of 45,750 young men who had been asked about their drug use when they were conscripted into the Swedish army. From analysis of these data, Allebeck and his colleagues1 reported in 1987 that conscripts who had used cannabis more than fifty times were six times more likely to develop schizophrenia over the next fifteen years than those who had never used it (Figure1).

Cerebrum - January 2015 - figure 1

Because only one study existed, most psychiatrists reassured themselves that the cannabis users probably were destined for schizophrenia before they started smoking. As a result, Allebeck’s findings were mostly ignored. Even the prestigious medical journal The Lancet, which had published Allebeck’s paper, carried an editorial in 1995 that restated the prevailing medical view that “t he smoking of cannabis, even long term, is not harmful to health.”2

Nevertheless, with the help of a young psychiatrist, Anton Grech, I began looking at patients who had smoked cannabis and been admitted to the Maudsley Hospital in London with a diagnosis of psychosis. Our aim was to see what happened to the ones who continued to use cannabis. If, as some suggested, psychotic patients used cannabis to “self-medicate” or otherwise help them to cope with their illness, then one might expect the persistent cannabis users to have a better outcome. But we found the opposite; four years later, the patients who continued to use cannabis were much more likely to still have delusions and hallucinations.3 Many studies have replicated the findings.4-6

So, if smoking cannabis exacerbates established psychosis, might it play a causal role too?This question provided the impetus for various research groups to try to replicate the Swedish army study by following-up samples of young people in the general population, divided into cannabis users and non-users. Since 2002, a series of ten such studies have reported that individuals who used cannabis at the baseline evaluation had a greater risk of subsequently developing psychotic symptoms and indeed full-blown schizophrenia than non-users.7-18 Other studies of cannabis users who had sought medical care showed that they had a marked increased risk of subsequent schizophrenia.19-20 Such unanimity is rare in psychiatric epidemiology.21

A Hostile Reaction

Much of the scientific establishment greeted these findings with hostility, as did people advocating a more liberal attitude regarding cannabis use. My colleagues and I were accused of being closet prohibitionists; some suggested we were experiencing our own kind of “reefer madness.” Critics suggested that people using cannabis were doing so because they were odd and destined to develop schizophrenia anyway.22

But in a study of young people who had been scrutinized intensely from birth in Dunedin, New Zealand, we were able to exclude those who already appeared psychosis-prone at age eleven. We still found a link between cannabis use and later schizophrenia, even when we excluded the effects of other drugs known to increase risk of psychosis.7 Another criticism was that maybe some people were taking cannabis in an attempt to ameliorate symptoms of psychosis or its precursors. However, a second New Zealand study, this time from Christchurch, showed that once minor psychotic symptoms developed, people tended to smoke less.8

Eventually the sheer volume of data convinced European and Australian psychiatrists of a link. Cannabis is now generally accepted as a cause of schizophrenia 23-24 (though less so in North America, where this topic has received little attention). Argument does continue over just how significant cannabis-associated psychosis is. In different countries, the proportion of schizophrenia attributed to cannabis use ranges from 8 to 24 percent, depending, in part, on the prevalence of cannabis use.25

Excess Becomes a Major Concern

Most people enjoy cannabis in moderation and suffer few or no adverse effects. People take comfort in knowing that some of the most celebrated role models on the planet—Paul McCartney, Oprah Winfrey, and Barack Obama, for example—have admitted to smoking cannabis with no ill effect. But the scientific consensus is that, although there is no convincing evidence of a link to anxiety26 or depression,27 cannabis can lead to psychosis when consumed in large amounts. The bottom line: daily users who smoke large amounts are increasing their risk of schizophrenia.

Nevertheless, the vast majority of users won’t become psychotic. Indeed, when young people who have developed schizophrenia after years of smoking cannabis are asked whether they think their habit may have contributed, they often say, “No, my friends smoke as much as I do, and they’re fine.”  It appears that some people are especially vulnerable.

Not surprisingly, people with a paranoid or “psychosis-prone” personality are at greatest risk, alongside people with a family history of psychosis.28 Research also suggests that inheriting certain variants of genes that influence the dopamine system, which is implicated in psychosis, may make some users especially susceptible; examples of such genes include AKT1, DRD2, and possibly COMT.29-31

Another important question is:  Are some types of cannabis more risky than others?

The Changing Nature of Cannabis

The cannabis plant is thought to originate from either central Asia or the foothills of the Himalayas. It produces compounds known as cannabinoids in glandular trichomes, mostly around the flowering tops of the plant.  Recreational cannabis is derived from trichomes and has been traditionally available as herb (marijuana, grass, weed) or resin (hashish, hash); the former most common in North America and the latter in Europe. Cannabis acts on the CB1 cannabinoid receptor, part of the endocannabinoid system, which helps to maintain neurochemical stability in the brain.   The cannabis plant produces more than 70 cannabinoids, but the most important are tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is responsible for the “high” that users enjoy. It activates the cannabinoid CB1 receptor, which is one of the most widespread receptors in the brain.

The proportion of THC in traditional marijuana and resin in the 1960s was approximately 1 to 3 percent. The potency of cannabis began to rise in the 1980s, when cannabis growers such as David Watson, commonly known as “Sam the Skunkman,” fled the Reagan-inspired “War on Drugs” and brought cannabis seeds to Amsterdam, where it could be sold legally in “coffee shops.” Together with Dutch enthusiasts, they experimented to produce more potent plants. This set the trend for a slow but steady increase in a new variety of marijuana called sinsemilla, harvested from unpollinated female flowers (often called “skunk” because of its strong smell). By the early years of the twenty-first century in England and Holland, respectively, the potency of sinsemilla, as measured by the proportion of THC, had risen to between 16 and 20 percent, and it had taken over much of the traditional market from resin. 32-33  

In 1845, French psychiatrist Jacques-Joseph Moreau (nicknamed “Moreau de Tours”) took cannabis himself in the appropriately named Club de Hashischins, and gave it to some of his students and patients.34 He concluded that cannabis could precipitate “acute psychotic reactions, generally lasting but a few hours, but occasionally as long as a week.” However, since then surprisingly little formal scientific research has explored THC’s effects in humans. 

One of the first THC studies was conducted by Paul Morrison, a Scottish psychopharmacologist in our group at King’s College London, who gave the ingredient intravenously to healthy and eager young volunteers.35 Their reactions ranged from euphoria to suspicion, paranoia, and hallucinations. Later, he and Amir Englund36 pretreated their volunteers with cannabidiol (CBD), the other main ingredient of traditional cannabis), before giving them intravenous THC; the effects of the latter were much diminished. Thus, CBD appeared to counter the psychotogenic effects of THC. A German clinical trial supports this idea: Marcus Leweke 37 found that CBD had antipsychotic actions equivalent to a standard antipsychotic, amisulpride, in patients with schizophrenia.  

High-potency types of cannabis such as sinsemilla (skunk) differ from traditional forms not only in the amount of THC they contain but also in the proportion of CBD. Interestingly, plants bred to produce a high concentration of THC cannot also produce a lot of CBD, so the high THC types of cannabis contain little or no CBD.32

Might high potency types of cannabis be more likely, therefore, to induce psychosis than traditional forms? To examine this question, my wife, Marta Di Forti, a psychiatrist supported by the UK Medical Research Council, compared the cannabis habits of 410 patients who were admitted to the Maudsley Hospital with their first episode of psychotic disorder to those of 390 controls in the local population. Those who had been using high-potency cannabis (skunk) had a much higher risk of psychosis than users of resin.25,38-39 People using skunk-like cannabis on a daily basis were five times more likely than non-users to suffer from a psychotic disorder while users of traditional resin did not differ from non-users. Another study which tested hair for cannabinoids showed that those users with both detectable THC and CBD in their hair had fewer psychotic symptoms than those with only THC.40

Thus the increasing availability of high-potency types of cannabis explains w hy psychiatrists should be more concerned about cannabis now than they were in the 1960s and 1970s. The trend towards greater potency is not slackening with new forms of resin and resin oil being reported to contain up to 60 percent.41 These particular very potent forms remain unusual but s ynthetic cannabinoids (often termed “spice” or “K2”) are now commonly advertised and sold on websites that keep within the law by labelling their products as incense—or adding “not for human consumption.” While THC only partially activates the CB1 receptor, most spice/K2 molecules fully activate the receptor and therefore are more powerful. Consequently, acute adverse reactions are more common. A survey of 80,000 drug users showed that those who used synthetic cannabinoids were thirty times more likely to end up in an emergency room than users of traditional cannabis.42 The agitation, anxiety, paranoia, and psychosis that can result from synthetic cannabinoids use have been dubbed “spiceophrenia.”43-44

Dependence and Cognitive Impairment Remain Controversial

While psychological dependence and tolerence occur, the issue of physical dependence remains hotly debated. Advocates point to an apparent absence of acute withdrawal symptoms from cannabis (there have been no studies to date examining specifically high THC users). Under ordinary circumstances, withdrawal symptoms are absent because cannabis remains in the body for several weeks—so withdrawal is very gradual and not obvious, though anxiety, insomnia, appetite disturbance, and depression can develop .  Some claim that 10 percent of people who experiment with cannabis will develop dependence and that rates of dependence among daily users are at least 25 percent . Whether or not such figures are true, cannabis dependence is an increasingly common cause of those seeking help in Australia, Europe, and North America.45-47  

Another controversial issue is cognitive impairment. THC disrupts the hippocampus, the area of the brain crucial to memory. When Paul Morrison induced psychotic symptoms by giving intravenous THC to volunteers, transient cognitive impairment also emerged . Such impairment likely is why drivers under the influence of cannabis are at double the risk of traffic accidents.47

Heavy users show cognitive impairment, but disagreement continues over what happens when they stop. Some studies suggest they can recover fully, while others indicate that only partial recovery is possible.48 One (as yet unreplicated) study that provoked enormous concern was a report by Madeleine Meier and her colleagues, based on the Dunedin study.49 This suggested that persistent cannabis use over several decades causes a decline of up to eight points in IQ.

One possible explanation for the inconsistent cognitive findings is that the effects on cognition might depend on the age at which cannabis use began. Harrison Pope and colleagues examined long-term heavy cannabis users and found that it was those who initiated cannabis use before age seventeen who showed lower verbal IQ scores.50  Meier also found greater decline in those in her Dunedin cohort who started using in adolescence. 49

Other studies have implicated an association between adolescence cannabis use and poor educational achievement. Edmund Silins and colleagues reviewed more than 2,500 young people in Australia and found that that daily cannabis use before age seventeen was associated with “clear reductions” in the likelyhood of completing high school and obtaining a university degree.51

Researchers have raised similar questions regarding age of intiation and risk of psychosis. In our Dunedin study, we found that people who started to use cannabis at age eighteen or later showed only a small, non-significant increase in the risk of schizophrenia-like psychosis by age twenty-six. But among those starting at age fifteen or earlier, the risk increased fourfold.7 (Figure 2) Other studies have reported similar disparities.21  

 

Cerebrum - January 2015 - figure 2

 

Experimental studies in rodents have revealed that THC administration produced a greater impact on cognitive function in juvenile than in adult rats.21 Also, some recent brain imaging studies of long-term, very heavy cannabis using people have claimed to find detectible brain changes especially in those who started in adolescence.52-54 Although the imaging studies remain contentious, a possible explanation is that beginning cannabis use at an age when the brain is still developing might permanently impair the endocannabinoid system, and impact on other neurotransmitters such as dopamine system21—known to be implicated in both learning and in psychosis. 

Implications

Cannabis attitudes are changing globally. Uruguay has legalized its use, as have four American states. In addition, seventeen states have decriminalized cannabis, while twenty-three others have passed “medical marijuana” laws on the basis that it helps people with chronic pain and symptoms associated with chemotherapy. A curious divide has opened up between North America and Europe. In the U.S., cannabis use in young people has increased since the mid-1990s as the number regarding use of cannabis as risky has fallen.55 In contrast, use has fallen in many European countries, partly because of greater knowledge of the risks to mental health. In England for example, in 1998, 26 percent of people ages sixteen to twenty-four admitted to having used cannabis in the previous year. By 2013, that number had declined to 15 percent.56

As they consider the future of legal cannabis use, legislators and politicians need to balance the enjoyment of the many with the potential for harm. That challenge is displayed in the United Kingdom, where pro- and anti-cannabis lobbies have engaged in a raucous argument. In 2004, the government took the advice of the Advisory Council on the Misuse of Drugs that the use of cannabis had no serious adverse effects, and lowered restrictions on the drug. The following year, the Advisory Council reversed its view and accepted the evidence that linked cannabis to psychosis. Some newspapers that had campaigned for liberalization responded by turning on the “liberal” politicians. By 2007, the media clamor had reached such a pitch that the government increased restrictions again. Now pressure is building up once again for liberalization.57  

In picking their way through the conflicting views, politicians and regulators need to recognize that “medicinal marijuana” has become largely a cover for introducing recreational use by the marijuana industry,58 and that unscrupulous and increasingly wealthy doctors are involved. However, research into the numerous components of cannabis should be encouraged since, like research into opiates, it may produce drugs with important medical uses. Individual cannabinoid components can then be subject to trials measuring their effectiveness for a variety of ailments (eg multiple sclerosis, epilepsy) in the same way any other proposed drug is evaluated. When effective, it should be introduced for prescription by doctors; several cannabinoid drugs already have become available in this manner.

But we must be careful, since the evidence we have reviewed suggests that cannabis, like other psychotropic drugs, has negative as well as positive effects. When you consider that almost 200 million people worldwide use cannabis,59 the number of people who suffer cannabis-induced psychosis is likely to be in the millions, and the number at risk for developing serious mental health problems becomes a huge concern.

Europeans are watching the evolution of the cannabis debate in the U.S. with great interest. Decriminalization and legalization of cannabis and synthetic cannabinoids are all on the table. Will l egalization mean an increase in consumption? Will this result in greater use by those in their early teens who seem most susceptible to adverse effects? Will the mental health and addiction services be able to cope? How will educational campaigns regarding the risks of regular use of high-potency cannabis or synthetic cannabinoids play out? Might a simple genetic test reveal who is likely to suffer adverse mental effects? As cannabis use continues to win acceptance, as many questions as answers remain.

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Comments


Missing the blindingly obvious?

Derek Williams

1/12/2015 5:01:19 PM

Robin Murray wrote: " Cannabis is now generally accepted as a cause of schizophrenia (though less so in North America, where this topic has received little attention)" Now why might that be? There is, after all, a very strong anti-cannabis prohibition effort in the US, it would seem inconceivable that such an issue would not have been exploited by them, unless of course, it doesn't exist. So can we suggest a possible reason Robbin Murray's observations are true here but not in the US? Is perhaps there any significant difference in the way cannabis is used here and in the US? Well, as it happens, there is. In Europe cannabis is generally smoked with tobacco, in the US it isn't. Tobacco is known to be linked to the development of serious mental illness and the vast majority of ill people are heavy tobacco smokers. How many of the studies Robin Murray quotes investigated the possible confounding effects of tobacco? The Answer oddly enough is "none". How many looked at users of pure cannabis? Again, the answer is almost certainly none. The use of other drugs was often controlled for, but not tobacco. Secondly, he points to the increased availability of so called "skunk" without highlighting the fact that UK drugs policy has been responsible for restricting the supply of the traditional imported hashish from North Africa. Had this supply not been restricted, would there have been the demand for home produced cannabis? In any case the increase in potency (ie decrease in CBD content) has occurred within the past 40 years under the prohibition regime, having not occurred in the 4,000 years of recorded human interaction with cannabis prior to that. Now correlation doesn't prove causation, but it does look like the policy Robin Murray seems to support has caused the problem he identifies. Finally, cannabis law reform isn't "liberalising", it's about making cannabis a properly controlled and regulated drug so that we know its strength, potency, purity and we know who sells it and where from.

Misuse of the term 'skunk'

Peter Reynolds

1/12/2015 2:32:07 PM

I have previously addressed Sir Robin in person on this issue. Skunk is one of hundreds of strains of cannabis and by no means the one with the highest THC content. The word has been selected and promoted by the tabloid press because of its obvious, sensationalist, negative connotations. What is truly disgraceful is how some scientists have started to use the term in exactly the tabloid sense. This is the very opposite of science and any scientist you hear using the term (except to refer to the specific strain) has disqualified him/herself from using the title scientist. If it is the THC:CBD ratio that is of concern they should talk about precise figures, not in tabloid generalisations. http://www.clear-uk.org/the-disgraceful-misuse-of-the-term-skunk-by-those-who-call-themselves-scientists/

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