Nicky Penttila, The Dana Foundation
Wednesday, November 10, 2010

The Great Brain Books, Revisited

By: Johanna Goldberg, M.S.L.I.S.

The Dana Foundation has updated its list of the top books about the brain--with your help.

In 1999, Cerebrum published a list of books about the brain, guiding regular readers to “the great books, past and present, that capture the unfolding story of the brain and how brain research is changing our ideas about memory and emotion, life span and language, neurological disorders and psychiatric syndromes.”

Eleven years later, the need for such a list is even greater—more than 30,000 brain-related books in English are in print or will soon be published, according to Bowker’s Books in Print. What is a reader to do?

We decided to update our list, with help from our readers and our science experts. To draw out the best current and classic books from the crowded field, we selected 10 categories, based on our earlier list. Then we opened up a poll to readers, asking them to nominate their favorites in as many of the categories as they wished.

More than 70 of you responded—thank you! Your choices were forwarded to Dana Alliance members, who were asked to send in their top choices. After we heard from more than 30 members, we made a final tally, which was reviewed by Cerebrum’s scientific advisors.

Here are the top three or four books in each category listed in order of the number of votes they received, along with some runners-up. Many books fit in multiple categories; if a book is listed in a category that doesn't interest you, don’t let that stop you from taking a look at it—it may have been pigeonholed to fit the format. Of course, there are many other books in each category worth reading; this list is just a starting point. We hope it will lead you to enjoy some great science writing.

1. General Books About the Brain

The Brain that Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science  
By Norman Doidge. Viking, 2007.

This book was far and away the most popular choice of readers. Exploring the plasticity of the brain—something that was only recently proven to exist—Dr. Doidge uses case studies to discuss how people remember, recovery from injury, love, and learn.

Rhythms of the Brain  
By Gyorgy Buzsaki. Oxford University Press, 2006.

How did our brains evolve, and what makes them work? Dr. Buzsaki looks into how coordinated neuronal firing developed and hypothesizes that it plays a large role in the brain’s many functions, including information processing and retrieval.

The Other Brain : From Dementia to Schizophrenia, How New Discoveries About the Brain Are Revolutionizing Medicine and Science  
By R. Douglas Fields. Simon & Schuster, 2010.

Until recently, neurons were the brain cell that got all the attention, but now it's clear that glial cells are more than just glue that holds the brain together. Dr. Fields looks at the many functions of glia that are being uncovered and the scientific breakthroughs that could come from a better understanding of these cells.


Liars, Lovers, and Heroes: What the New Brain Science Reveals About How We Become Who We Are  
By Steven R. Quartz and Terrence J. Sejnowski. William Morrow, 2002.

The Mind Machine  
By Colin Blakemore. BBC Books, 1994 (revised edition). Note: This book is out of print, but used copies are available.

The Future of the Brain: The Promise and Perils of Tomorrow's Neuroscience  
By Steven Rose. Oxford University Press, 2006.

The Body Has a Mind of Its Own  
By Sandra Blakeslee and Mathew Blakeslee. Random House, 2008.

2. Neuropharmacology and Brain Chemistry

Essential Psychopharmacology: The Prescriber's Guide  
By Stephen M. Stahl. Cambridge University Press, 2009 (3rd edition).

Though this may not be a book for a layperson to read cover to cover, it is valuable as a reference guide, detailing the ways in which specific drugs are prescribed, how they work, generic options, and potential side effects.

Listening to Prozac: A Psychiatrist Explores Antidepressant Drugs and the Remaking of the Self  
By Peter Kramer. Penguin, 1997.

This classic best seller was also a pick in our 1999 survey. Dr. Kramer explores how Prozac is used in America, looking critically at the ways in which the drug can alter personality and the ethical questions that such changes raise.

Before Prozac: The Troubled History of Mood Disorders in Psychiatry  
By Edward Shorter. Oxford University Press, 2008.

Dr. Shorter argues that actions by the U.S. Food and Drug Administration as well as doctors' reliance on the Diagnostic and Statistical Manual of Mental Disorders (DSM) have led to an overwhelming use of ineffective drug treatments and questionable diagnoses for mood disorders, thus hobbling modern psychiatry.


Better Than Prozac: Creating the Next Generation of Psychiatric Drugs  
By Samuel H. Barondes. Oxford University Press, 2003, 2005.

3. Development and Life Span

Descartes' Baby: How the Science of Child Development Explains What Makes Us Human  
By Paul Bloom. Basic Books, 2005.

Even as infants we are aware of a physical world and a world of mental states, argues Dr. Bloom. This dualistic view forms the ways in which we think, feel, and act, and encourages us to experience religion, moral reasoning, and an appreciation for art and literature.

Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School  
By John Medina. Pear Press, 2008.

Dr. Medina puts a practical spin on neuroscience, turning what scientists know about the brain into advice for how we live our daily lives, including how we pay attention, what we remember, and how we raise children.

Aging with Grace: What the Nun Study Teaches Us About Leading Longer, Healthier, and More Meaningful Lives  
By David Snowden. Bantam, 2001.

Dr. Snowden began studying 678 Catholic nuns in 1986. In this book, he explores the results of his longitudinal study, examining how women living in a controlled environment age differently from one another. What might cause one nun, for example, to develop dementia while another remains lucid?

The Science of Parenting  
By Margot Sunderland. DK Adult, 2008.

The way parents raise their children has a lasting impact. Dr. Sunderland turns to science to give parents and caregivers advice on how to react to specific behaviors and the ways in which a child’s brain develops.


What's Going on in There? How the Brain and Mind Develop in the First Five Years of Life  
By Lise Elliot. Bantam, 2000. 

4. Cognition, Learning, and Memory

The Man Who Mistook His Wife for a Hat and Other Clinical Tales  
By Oliver Sacks. Touchstone, 1985.

Here’s another book from the 1999 list—this time around, it was endorsed by nearly one-third of the responding Dana Alliance members. Dr. Sacks uses a patient-centered approach to explore neurological disorders including visual agnosia, aphasia, and Korsakoff's syndrome (an inability to form new memories).

The Number Sense: How the Mind Creates Mathematics  
By Stanislas Dehaene. Oxford University Press, 1999.

Our brain is wired for mathematics from birth, writes Dr. Dehaene. Imaging technologies have allowed researchers to begin identifying the regions of the brain responsible for computation. The book also explores the invention of number systems and whether people have an innate number sense.

The Seven Sins of Memory: How the Mind Forgets and Remembers  
By Daniel L. Schacter. Mariner Books, 2002.

Dr. Schachter lays out his “seven sins of memory” (transience, absentmindedness, blocking, misattribution, suggestibility, bias, and persistence) and explains why the brain evolved in such a way that memory lapses can be beneficial, if irritating. He also delves into the serious consequences that may result from faulty memories.


Save Your Brain: The 5 Things You Must Do to Keep Your Mind Young and Sharp  
By Paul Nussbaum. McGraw-Hill, 2010.

Smart Moves: Why Learning Is Not All in Your Head  
By Carla Hannaford. Great River Books, 2005.

Reading in the Brain: The Science and Evolution of a Human Invention  
By Stanislas Dehaene. Viking, 2009.

5. Consciousness

Synaptic Self: How Our Brains Become Who We Are  
By Joseph LeDoux. Viking, 2002.

Where does the self come from? According to Dr. LeDoux, synapses (the pathways between neurons through which messages are conveyed) are what allow people think, feel, and act—to be human. Synapses allow the brain to store information, leading to long-term memories and ultimately a sense of self.

Train Your Mind, Change Your Brain: How a New Science Reveals Our Extraordinary Potential to Transform Ourselves  
By Sharon Begley. Ballantine Books, 2007.

Science writer Sharon Begley bridges neuroscience and Buddhism in a book that explores how neuroplasticity can affect mood and promote happiness. Studies of meditation and mindfulness, writes Ms. Begley, indicate that people can be taught to be compassionate and to better focus their attention.

Cognition, Brain, and Consciousness: Introduction to Cognitive Neuroscience  
Edited by Bernard J. Baars and Nicole M. Gage. Academic Press, 2010.

This is an introductory textbook for undergraduate and graduate students. Still, it offers a comprehensive look at issues in cognitive neuroscience, presenting the latest research in a thematic way.


Wider Than the Sky: The Phenomenal Gift of Consciousness  
By Gerald Edelman. Yale University Press, 2004.

The Neurology of Consciousness: Cognitive Neuroscience and Neuropathology  
Edited by Steven Laureys and Giulio Tononi. Academic Press, 2008.
Note: This is a textbook, and might be written at a higher level than the general lay reader is used to.

The Mindful Brain: Reflection and Attunement in the Cultivation of Well-Being  
By Daniel J. Siegel. W. W. Norton, 2007.

6. The Senses

A Natural History of the Senses  
By Diane Ackerman. Vintage, 1991.

Ms. Ackerman travels the world as she explores the senses, looking at the culture and science behind touch, smell, sight, sound, and taste in this national best seller.

Eye, Brain, and Vision  
By David Hubel. Henry Holt, 1995.

A Nobel laureate for his work in the visual system, Dr. Hubel describes how the human eye works and how the brain processes visual information. Diagrams and illustrations combine well with his clear writing. This book was also a selection in 1999. Note that new copies may be difficult to track down.


The Great Pheromone Myth  
By Richard L. Doty. Johns Hopkins University Press, 2010.

7. Emotion and Behavior

The Emotional Brain: The Mysterious Underpinnings of Emotional Life  
By Joseph LeDoux. Simon & Schuster, 1998.

Another book that was also selected in 1999, Dr. LeDoux’s exploration of the neurological workings of emotions still appeals to readers. Studying emotions from a biological—and not just a psychological—perspective leads to a better understanding of human experience. Dr. LeDoux pays special attention to his main area of research, the amygdala.

How We Decide  
By Jonah Lehrer. Houghton Mifflin, 2010.

[Editor's note: The publisher pulled this book from distribution in March 2013. This article was published in 2010.]

Why do we make the decisions we make? Mr. Lehrer uses real-life examples—from the crash landings of pilots to the bets of poker players—to make the neuroscience behind decision making accessible, useful, and appealing to readers.

Descartes' Error: Emotion, Reason, and the Human Brain  
By Antonio R. Damasio. Penguin, 2005.

According to Descartes, “I think, therefore I am.” According to Dr. Damasio, you can’t think without feelings and emotions. He uses case studies of people with frontal lobe injuries to show just how connected emotions, personality, and decision making are. The 1995 edition of this book was included on the 1999 list.


Looking for Spinoza: Joy, Sorrow, and the Feeling Brain  
By Antonio Damasio. Mariner Books, 2003.

The Temperamental Thread: How Genes, Culture, Time, and Luck Make Us Who We Are  
By Jerome Kagan. Dana Press, 2010.

Emotional Intelligence: Why It Can Matter More Than IQ  
By Daniel Goleman. Bantam, 1995, revised edition 2005.

8. Diseases and Disorders

The Dana Guide to Brain Health: A Practical Family Reference from Medical Experts  
Edited by Floyd Bloom, M. Flint Beal, and David J. Kupfer. Dana Press, 2006.

Dana’s practical reference guide offers information on the brain through life, specific diseases and disorders, normal brain processes, learning and memory, and emotions and behavior.

Phantoms in the Brain: Probing the Mysteries of the Human Mind  
By V. S. Ramachandran and Sandra Blakeslee. HarperPerennial, 1999.

Dr. Ramachandran and Ms. Blakeslee investigate neurological oddities, from hallucinations to phantom limbs. Such strange cases lead to more-general conclusions about the brain’s circuitry and plasticity.

Brave New Brain: Conquering Mental Illness in the Era of the Genome  
By Nancy Andreasen. Oxford University Press, 2001, 2004.

Dr. Andreasen discusses the causes and effects of schizophrenia, manic depression, anxiety disorders, and dementia in the context of the overlapping fields of genetics and neurobiology. The intersection of these fields could improve our understanding of the mechanisms behind the disorders and lead to new methods of treatment.


My Stroke of Insight: A Brain Scientist's Personal Journey  
By Jill Bolte Taylor. Penguin, 2009.

9. Memoirs and Personal Experience

In Search of Memory: The Emergence of a New Science of Mind  
By Eric R. Kandel. W. W. Norton, 2007.

In Search of Memory was the most popular selection of the responding Dana Alliance members. Dr. Kandel reflects on his five decades of research—including his Nobel Prize–winning work on the role of synapses in learning and memory function—and his family’s escape from Nazi Germany.

The Diving Bell and the Butterfly: A Memoir of Life in Death  
By Jean-Dominique Bauby. Vintage, 1998.

At the age of 44, Mr. Bauby, then editor in chief of Elle magazine, suffered a stroke that left him a victim of locked-in syndrome, able to move only one eyelid. In this astonishing book, painstakingly dictated one letter at a time, he looks back on his life and details the realities of being trapped inside his body.

A Primate's Memoir: A Neuroscientist's Unconventional Life Among the Baboons  
By Robert M. Sapolsky. Scribner, 2002.

For more than two decades, Dr. Sapolsky studied the social behavior of baboons in Kenya. Here, he chronicles his field studies, looking not only at the lives of the baboons but also at the changing life in Africa and the challenges and personalities he encountered away from camp.


An Unquiet Mind  
By Kay Redfield Jamison. Knopf, 1997.

Recollections of My Life  
By Santiago Ramon y Cajal. MIT Press, 1989.

10. The Brain in Relation to Other Fields

Spark: The Revolutionary New Science of Exercise and the Brain  
By John Ratey. Little, Brown, 2008.

Exercise not only tones the body, it also benefits the brain. In this guide, Dr. Ratey details the many ways in which physical activity is advantageous to brain processes—for example, it can stimulate the production of neurons, help ward off dementia, and improve mood. The book also gives tips on how to take charge of your exercise regime.

This Is Your Brain on Music  
By Daniel J. Levitin. Dutton Adult, 2006.

In approaching music from the point of view of a cognitive neuroscientist, Dr. Levitin also draws on his earlier career as a rock musician and music producer. He provides a neurological explanation of the emotional response that music can elicit, using music as a window through which the brain can be understood.

Proust Was a Neuroscientist  
By Jonah Lehrer. Houghton Mifflin Harcourt, 2007.

Scientists aren’t the only ones to make brain-related discoveries. Mr. Lehrer chronicles how Walt Whitman, George Eliot, Auguste Escoffier, Marcel Proust, Paul Cézanne, Igor Stravinsky, Gertrude Stein, and Virginia Woolf made scientific observations that researchers required many more years to discover.


The Black Swan: The Impact of the Highly Improbable  
By Nassim Nicholas Taleb. Random House, 2007.

About Cerebrum

Bill Glovin, Editor in Chief
Carolyn Asbury, Ph.D., consultant

Scientific Advisory Board

• Joe Coyle, the Eben S. Draper Chair of Psychiatry and Neuroscience at Harvard Medical School; director of the Laboratory for Psychiatric and Molecular Neuroscience; former editor of JAMA Psychiatry

• Martha Farah, Annenberg Professor in Natural Sciences, professor of psychology, and director of the Center for Neuroscience & Society at the University of Pennsylvania

• Pierre Magistretti, professor in the Brain Mind Institute, EPFL, Center for Psychiatric Neuroscience, Department of Psychiatry - CHUV/UNIL, Switzerland

• Helen Mayberg, director of Center for Advanced Circuit Therapeutics for the Icahn School of Medicine at Mount Sinai

• Bruce McEwen, Alfred E. Mirsky Professor; head of the Harold and Margaret Milliken Hatch, Laboratory of Neuroendocrinology at the Rockefeller University

• John H. Morrison, director of the California National Primate Research Center and professor in the Department of Neurology, School of Medicine, UC Davis

• Harald Sontheimer, I. D. Wilson Chair and professor and executive director, Virginia Tech School of Neuroscience, Commonwealth Eminent Scholar in Cancer Research, and director of the Center for Glial Biology in Health, Disease & Cancer, Virginia Tech Carilion Research Institute

• Stephen Waxman, founding director of Yale University’s Neuroscience & Regeneration Research Center and the Flaherty Professor of Neurology, Neurobiology, and Pharmacology

• Chuck Zorumski, Samuel B. Guze Professor of Psychiatry and Professor of Neurobiology, department head, psychiatry director of the Taylor Family Institute for Innovative Psychiatric Research and Cynthia S. Smith, M.B.A., executive director of the Department of Psychiatry, Washington University School of Medicine

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