by Roy Hamilton, M.D.
This Phase II study will investigate whether responses by aphasia patients to a form of non-invasive brain stimulation, called transcranial magnetic stimulation, predict their capacity for brain plasticity and recovery of language and motor function....Read more >
by Roy Hamilton, M.D.
Researchers will undertake Phase I of a planned two-phase study to determine whether responses by aphasic stroke patients to a form of non-invasive brain stimulation, called transcranial magnetic stimulation, predict their capacity for brain plastici...Read more >
by Xin Jin, Ph.D.
This cellular imaging study in the Parkinson’s disease animal model will explore which of two hypothesized neural signaling problems is responsible for loss of voluntary motor control. People with Parkinson’s disease (PD) develop a characteristic gai...Read more >
by Peter de Blank, M.D., MSCE
This first phase of a planned two-phase study will determine whether it is feasible to use two imaging techniques in very young children with optic glioma. If feasible, the investigators propose a second phase to determine if the combined i...Read more >
by Jonathan Peelle, Ph.D.
This study will investigate how common age-related hearing loss changes brain structure and function, and what consequences these neurobiological effects have on understanding and remembering speech.
Behind only arthritis and hypertension, hearing l...Read more >
by Jong Yoon, M.D.
This study will examine whether high dopamine levels, as measured by high resolution fMRI, correlates with the onset of psychosis in schizophrenia and can serve as a diagnostic and therapeutic biomarker.
The prognosis for schizophrenia is poor. No...Read more >
by Andy Shih, Ph.D.
Through studies in mice, researchers will seek to improve MRI detection of tiny blockages in the brain’s small blood vessels that can lead to vascular dementia. Their findings may help clinicians identify at-risk patients and implement early preventi...Read more >
by Mary-Frances O'Connor, Ph.D.
will use fMRI imaging and other measures in 40 adults whose spouses have
recently passed away to determine whether an oxytocin nose spray reverses signs
of complicated (intense) grief and therefore might lead to an effective
treatmen...Read more >
by Brian Berman, M.D., M.S.
will combine PET and fMRI imaging in patients with cervical dystonia to see if
deficits in the neurotransmitter GABA alter the brain’s sensorimotor circuit to
produce the disorder’s characteristic involuntary muscle contractions that
...Read more >
by Scott Slotnick, Ph.D.
techniques in patients and healthy volunteers may identify a biomarker for
diagnosing and assessing treatments for frontal lobe diseases and injuries that
produce visual memory problems, such as Alzheimer’s and other dementing
diseases, ...Read more >
by Robert J. Young, M.D. and Ingo K Mellinghoff, M.D.
Investigators will advance a new MR
spectroscopy (MRS) imaging technique in patients to provide fast and reliable
indicators of deadly brain tumor progression and response to experimental
treatments.Brain tumors may be malignant or
benign. Malign...Read more >
by Ragy Girgis, M.D.
This research is designed to
determine whether MRS imaging (Magnetic Resonance Spectroscopy) can assess the
effects of experimental therapies in increasing glutamate levels to treat
schizophrenia. Currently schizophrenia is
treated with antipsy...Read more >
by Susan Schwab, Ph.D.
Investigators anticipate that
cellular imaging techniques in a multiple sclerosis mouse model will enable
them to identify the signaling that drives immune cell infiltration and
inflammation in autoimmune multiple sclerosis (MS) and assess whethe...Read more >
by Mikhail Shapiro, Ph.D.
The ultimate goal of this
planned two-phase study is to use a novel MRI imaging agent to show, in living
laboratory mice, how brain inflammation occurs and damages cells following
brain injury. Phase I will establish the imaging approach’s feasib...Read more >
by Conor Liston, M.D., Ph.D.
Researchers will use functional
magnetic resonance imaging (fMRI) techniques in patients with major depressive
disorder (MDD) to try to identify atypical connectivity patterns in the brain that
are biomarkers for diagnosing MDD and for predicting...Read more >
by Vikram Chib, Ph.D.
will undertake Phase I of a planned two-phase study to ultimately determine
whether a non-invasive brain stimulation technique helps schizophrenia patients
learn from positive rewards and reduce the “negative” symptoms that
character...Read more >
by Anthony Wagner, Ph.D.
Investigators will use high-powered
MRI imaging in older adults to see whether thinning of a tiny ribbon of tissue
in the brain’s hippocampus is a biomarker for pre-symptomatic Alzheimer’s
disease (AD) and can be used for screening and early dete...Read more >
by Christine DeLorenzo, Ph.D.
soon may be able to use a type of MRI imaging, called diffusion spectrum
imaging, to predict whether an individual patient with depression is likely to
respond to treatment with the class of antidepressants called SSRIs (selectiv...Read more >
by Corey McMillan, Ph.D.
Investigators will use MRI
imaging techniques to determine which of two proposed pathways young-onset
degenerative diseases use to spread in the brain, and to identify key brain changes
(biomarkers) that can be used to see if experimental the...Read more >
by Michael Yartsev, Ph.D.
Vocal learning, or the ability
to hear a sound or word, imitate it, and develop language is often thought of
as a required or necessary human ability, so much so that the lack of
appropriate language acquisition is a hallmark of many neurolog...Read more >
by Ming-Kai Chen, M.D., Ph.D.
a new PET imaging tracer outperform the currently used one in diagnosing Alzheimer’s
disease (AD) and in monitoring its progression? Diagnosing probable AD currently
relies on three major measures. One is whether there is a decrease i...Read more >
by Michael Zeineh, Ph.D., M.D.
inflammation arising from iron that is converted into an active state in the
brain be the third leg of the Alzheimer’s disease (AD) stool, joining the
abnormal proteins “amyloid” and “tau” as the hallmarks of AD? Stanford
investigators...Read more >
by Jun Hua, Ph.D.
MRI imaging may be able to pick up
early functional, vascular and metabolic brain changes in people with the
Huntington’s disease gene, potentially providing targets for treating this
devastating disease in its earliest stage. ...Read more >
by Jennifer Felger, M.S., Ph.D.
patients being treated for depression continue to lack motivation to engage in
potentially rewarding behaviors, like social interactions, and this problem may
be related to inflammation that impedes communication among reward-related
brain a...Read more >
by Guillermo Horga, M.D., Ph.D.
new molecular MRI imaging technique, called Neuromelanin-sensitive MRI
(NM-MRI), may be able to identify early signs of illness in people who are at a
high risk of developing Parkinson’s disease (PD) or schizophrenia. PD and schizophrenia each ...Read more >
by Mark Dunphy, D.O.
A new non-invasive PET imaging
tracer is showing promise for improving the ability to differentiate indolent
brain tumors from those that are aggressively growing, and for assessing the
aggressive tumor’s response to therapy, faster an...Read more >