Current Grantees

Behaviorally-guided DBS may treat psychiatric conditions involving impaired decision-making

by Emad N. Eskandar, M.D.

This neurosurgical research team will explore, at the neuronal level, how two brain networks normally drive the balance between safe and risky decision-making behaviors, and use the findings to design deep brain stimulation (DBS) strategies for modif...
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Neuroimaging of cognitive dysfunction due to soccer heading-related brain injury

by Michael L. Lipton, M.D., Ph.D.

Investigators will use diffusion tensor imaging (DTI), cognitive testing and gene studies to determine levels of sub-concussive head injury from soccer “heading” that increase the risk for adverse brain and cognitive functioning, and identify factors...
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Molecularly-targeted theranostic probes for EGFRmt+ brain tumors

by Michelle Bradbury, M.D., Ph.D.

Researchers will undertake studies in cancer patients and animal models to determine whether a PET imaging agent effectively carries and delivers a drug treatment for fighting metastatic cancers in the brain. The two most common metastatic cancers i...
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Impact of white matter injury on neural network development in premature infants

by Christopher Smyser, M.D.

Investigators will determine whether a new type of imaging, Functional Connectivity MRI, can effectively identify pre-term infants with injuries to the brain’s white matter (communication cables) that place them at greatest risk of developing cerebra...
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Cytoskeletal requirements for lymphocyte entry into the central nervous system

by Jordan Jacobelli, Ph.D

 Investigators will use real-time fluorescent multi-photon microscopy imaging in a mouse model of multiple sclerosis to define the routes that autoimmune T cells use to enter the brain and spinal cord and attack the myelin sheaths that insulate nerve...
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Functional imaging of the interaction between interferon-alpha and serotonin in the brain

by Francis E. Lotrich, M.D., Ph.D.

Investigators will use BOLD fMRI and “arterial spin labeling” to explore how neural transmission of serotonin is altered in people who develop major depressive disorder in the presence of inflammation, and to identify factors that may determine pre-e...
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Neural correlates of ECT response and relapse in major depressive disorder

by Chris Abbott, M.D., M.S.

This study will employ resting state fMRI to determine how electroconvulsive therapy exerts a therapeutic effect in patients with major depressive disorder, and to identify biomarkers that predict which patients are likely to relapse following ECT tr...
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