by Graeme F. Mason, Ph.D.
Investigators will use MRI imaging to determine if there is a direct link between a variant in a specific gene that may produce an increased susceptibility to alcohol dependence and two neurotransmitters that may be involved in addiction.Research has...Read more >
by Gero Miesenböck, M.D.
Yale researchers will use cellular optical imaging techniques in mice to study how the “feeding circuit,” located in the brain’s hypothalamus, balances appetite and satiety, and how this balance can be altered and lead to obesity.Research suggests th...Read more >
by Stephen C. Bunnell, Ph.D.
Researchers will use cellular imaging to identify interactions of immune system proteins that are implicated in the development of autoimmune and inflammatory diseases. The findings could lead to the development of drugs that selectively block these...Read more >
by Deyu Fang, Ph.D.
Researchers will use cellular imaging in mice to see how two proteins, which are essential for the early stages of immune T cell development, then degrade before they inhibit the T cells’ further growth and maturation. Understanding this normal degr...Read more >
by Tarik Haydar, Ph.D.
Researchers aim to use cellular imaging to determine how Down’s syndrome affects stem cells in the developing brain in a new animal model, and then determine how altered stem cell development relates to the behavioral abnormalities that the animals e...Read more >
by Herbert Tanowitz, M.D.
Investigators will study animals infected with malaria to try to learn how this infectious disease sometimes produces damage,called "cerebral malaria," to the brain The investigators hypothesize that in some people malaria infection causes their blo...Read more >
by Andrew Kung, M.D., Ph.D.
The investigators will refine their new model for evaluating the ability of experimental treatments to curtail growth of deadly brain tumors called gliomas. The new treatment evaluation method, if successful, will provide a faster and easier route f...Read more >
by Lynn Enquist, Ph.D.
Princeton researchers will image fluorescently labeled viral particles as they pass from one brain neuron to another in the mouse. This will provide information on how viral infection spreads within nervous system. The study also will demonstrate a ...Read more >
by John Laterra, M.D., Ph.D.
In this project, researchers will modify laboratory techniques so that they can be used to locate and quantify abnormal proteins, called “transcription factors,” that promote brain tumor growth. The techniques will be adapted for use first in animal...Read more >
by Dima Hammoud, M.D.
The investigators will use PET imaging to determine the underlying molecular changes that occur in the brains of people with AIDS who have developed AIDS-associated dementia. The results could lead to a better understanding of how dementia occurs an...Read more >
by Maiken Nedergaard, M.D., D.M.Sc.
Researchers will use two-photon cellular imaging in mouse models of two genetically determined “lysosomal storage” diseases, to determine how the diseases lead to accumulation of unprocessed metabolic products from brain cells, resulting in early ch...Read more >
by Bernardo L. Sabatini, M.D., Ph.D.
In the laboratory, Harvard researchers will use two-photon laser microscopy to visualize how activated proteins normally move into and out of brain cell synapses to enable one brain cell to communicate with another. Then, the investigators will imag...Read more >
by Rajeshwar Awatramani, Ph.D.
Northwestern University investigators will use molecular imaging in mice to learn how the brain cells that are destroyed in patients with Parkinson’s disease are initially developed. This insight may lead to an improved ability to develop stem cel...Read more >
by Pratik Mukherjee, M.D., Ph.D.
The researchers aim to improve the diagnosis and prognosis of traumatic brain injuries. They will combine two imaging techniques that they anticipate will enable clinicians to directly visualize both the brain’s functioning and its neuronal connecti...Read more >
by Lumy Sawaki, M.D., Ph.D.
Investigators will undertake a small-scale pilot study of the drug atomoxetine in adults undergoing rehabilitation following a stroke. They will use a technique called Transcranial Magnetic Stimulation (TMS) to determine whether the drug, combined w...Read more >
by Michael Stryker, Ph.D.
This study will determine the feasibility of using cellular imaging in mice to determine whether embryonic brain cells that are transplanted into the cerebral cortex integrate into neural networks and functionally replace the brain cells that have di...Read more >
by Sergio Paradiso, M.D., Ph.D.
Investigators will use fMRI imaging in adults to explore the possibility that depression in elderly people that occurs in the absence of feeling sad is associated with small blood vessel disease in brain regions involved in perceiving emotion. Suici...Read more >
by Jason R. Tregellas, Ph.D.
Colorado researchers will combine MRI imaging with genetic studies to explore the possibility that structural and functional brain deficits in people with schizophrenia are associated with a specific gene. If so, the research could identify new a ne...Read more >
by Lawrence Kegeles, M.D., Ph.D.
Investigators will image patients with schizophrenia to determine whether they have an imbalance in the chemicals that normally regulate levels of the neurotransmitter dopamine and whether this imbalance correlates with cognitive problems, such as me...Read more >
by Dean F. Wong, M.D., Ph.D.
Researchers will test in healthy human volunteers the safety and utility of a new PET imaging agent intended to be used to assess the effectiveness of various drugs used to treat psychiatric illnesses, such as schizophrenia, anxiety, depression, and ...Read more >
by Jose A. Esteban, Ph.D.
The investigators will use molecular imaging in laboratory animals to gain a better understanding of how brain wiring occurs, and continuously changes, through cognitive activities such as learning and memory. Neural networks form through brain c...Read more >
by Ione Fine, Ph.D.
Using MRI and fMRI in people who are blind at an early age and those who became blind later in life, the researchers will study how visual deprivation affects the visual cortex and how brain plasticity affects the cortex’s responses to non-visual sen...Read more >
by Prakash Kara, Ph.D.
Medical University of South Carolina investigators will undertake cellular imaging in laboratory animals to learn how information is transformed from the eye to the brain through neural circuits that produce vision. The results are anticipated to en...Read more >
by Satchidananda Panda, Ph.D.
Salk Institute investigators will use molecular imaging in transgenic” mice (containing human cells) to learn how subsets of neurons that comprise the brain’s Master Clock” work to synchronize sleep and wake cycles and numerous other functions, such ...Read more >
by Stelios Smirnakis, M.D., Ph.D.
This study will use fMRI imaging to examine contradictory findings about the nature and extent of reorganization of the visual cortex following retinal injury.Research has not demonstrated conclusive answers to several fundamental questions concernin...Read more >
by P. Read Montague, Ph.D.
Baylor researchers will use a new imaging technology they have developed to image simultaneously the brains of highly functioning individuals with autism engaged in social interactions. This is the first study of its kind and may provide insight in...Read more >
by Janet Soul, M.D., C.M., FCRPC
Researchers will use imaging to test the hypothesis that injury to brain cell axons (communication cables) in premature infants alters the brain cells, resulting in cognitive impairment.Research has found that 70 percent of premature infants weighing...Read more >
by Yanming Wang, Ph.D.
This study will determine whether a cellular PET imaging technique in mice can quantify the extent of myelination that occurs during development to insulate brain cell axons and help conduct electrochemical chemicals from one brain cell to another. ...Read more >
by Patrick McQuillen, M.D.
The investigators will combine two types of imaging to determine how congenital heart defects in newborns contribute to their subsequent development of motor problems, such as in walking.Two-thirds of children born with congenital heart defects later...Read more >
by Carols Portera-Cailliau, M.D., Ph.D.
How do the millions of brain cells establish billions of connections (i.e., synapses) with one another? How do they find and choose suitable partners with which to make synapses in the vastness of the immature brain? Can errors in synapse formation l...Read more >
by Susana Martinez-Conde, Ph.D.
Using fMRI BOLD imaging in normal adults, the researchers will determine how our brains “fill-in” normal blind spots that occur in our vision. This study will provide baseline information that can be used to explore how filling-in occurs following d...Read more >
by David Cummings, M.D.
University of Washington researchers will use a modified imaging technique to explore the molecular processes in the brain that are thought to control body weight and the development of obesity. Using MRS (Magnetic Resonance Spectroscopy) in animals...Read more >
by Nikolaus S. Trede, M.D., Ph.D.
The researchers will apply a new molecular imaging technique to see if it can help advance efforts to detect, treat, and identify the genetic bases for an autoimmune disease in zebrafish that is similar to autoimmunity in humans.Autoimmune diseases o...Read more >
by Jeffrey E. Segall, Ph.D
Investigators will use molecular imaging to determine whether immune “microglial” cells that reside in the brain interact with deadly brain tumor cells, enhancing the tumor cells’ entry into healthy brain tissues.Deadly brain tumors called “gliomas” ...Read more >
by Kathleen Zackowski, Ph.D., O.T.R.
Studying patients with multiple sclerosis (MS), researchers will determine whether two types of imaging techniques can quantify the extent of neural damage from acute exacerbations of the disease, and thereby help to predict the extent of recovery.MS...Read more >
by Tom Kerppola, Ph.D.
The researchers will use new cellular imaging methods to study how therapeutic agents that either stimulate or suppress immune cells are affected by proteins that regulate immune system responses.Proteins, which are expressed by genes to carry out sp...Read more >
by Gary Bassell, Ph.D.
Investigators will examine the normal role of a specific protein that is missing in males who have an inherited form of mental retardation in order to determine how this protein deficiency impairs cognitive development. The findings may lead to new ...Read more >
by Rajendra Badgaiyan, M.D.
The investigators will use PET with a molecular tracer to see if this approach can reveal the neurochemistry of dopamine transmission that is involved in human memory.The effects of impaired dopamine transmission on cognition in a number of neurologi...Read more >
by Gadi Goelman, Ph.D.
Based on the researchers’ Dana-supported demonstration that a new MRI imaging technique can non-invasively detect asynchronous firing of neurons, the investigators now will determine whether this abnormal firing occurs in patients with Parkinson’s di...Read more >
by James Olson, M.D., Ph.D.
Researchers will develop “smart contrast agents” that bind to specific brain cells involved in Parkinson’s and Huntington’s disease, enabling scientists to quantify brain cell loss in patients with these degenerative diseases. If effective, this tec...Read more >
by Ellen Winner, Ph.D.
Boston College researchers will use MRI and fMRI imaging to assess the effects of music training on cognition and investigate whether skills acquired in music training transfer to other cognitive functions, such as mathematical and verbal performance...Read more >
by Brian Schaefer, Ph.D.
These investigators will use cellular imaging to define the molecular processes that tumor cells use to block signals that ordinarily stimulate immune T cells to attack the tumor. The findings could lead to the development of new approaches to thera...Read more >
by Georges El Fakhri, Ph.D.
Harvard investigators have refined an imaging technique that can measure two events simultaneously in patients with Parkinson’s disease, Diffuse Lewy Body disease, and Alzheimer’s disease, to see if it can effectively diagnose each disease early. If...Read more >
by Robia Pautler, Ph.D.
Baylor researchers will combine MRI with a cellular imaging tracer in mice to see whether progressive accumulation of brain amyloid, a hallmark of Alzheimer’s disease, is associated with progressively slower movement of electrical signals along nerve...Read more >
by Julie Price, Ph.D.
Pittsburgh researchers seek to validate a new PET imaging tracer called Pittsburgh Compound B (“PIB”) that they have developed to identify brain amyloid deposits that occur well in advance of symptomatic Alzheimer’s disease. Thereafter, the team wil...Read more >
by Murray Grossman, M.D.
A genetic study may reveal the genetic basis for a language disability, and conversely, for the underlying capacity to develop and understand language. This is an imaging and genetic study of a subgroup of patients with a type of dementia that only ...Read more >
by John Morris, M.D.
Three studies would be undertaken to test the hypothesis that brain uptake of the new PET imaging tracer called PIB, by binding to a protein called amyloid, identifies the preclinical (asymptomatic) phase of Alzheimer’s disease. If the hypothesis is...Read more >
by David Zenisek, Ph.D.
Researchers will learn how disease-related proteins are recruited to brain cell “synapses," the junctions that connect one brain cell to another, and how these proteins are released by one brain cell and taken up by another during synaptic transmissi...Read more >
by Bradley Hyman, M.D., Ph.D.
This academic research study will examine how the first experimental therapeutic vaccine, designed to reduce brain accumulation of amyloid in Alzheimer’s disease, caused a life-threatening inflammatory response in some of the patients participating i...Read more >
by Ravinder Reddy, Ph.D.
A form of MRI imaging may provide a non-invasive indirect method to identify and quantify brain amyloid deposits in Alzheimer’s disease. Investigators at the University of Pennsylvania will try to validate this approach using a “humanized” mouse mod...Read more >
by Andrew Alexander, Ph.D.
By combining anatomical imaging with electrical recording techniques. scientists will characterize abnormalities in frontal lobe brain connections in patients with schizophrenia. This newly combined technique may reveal important neural abnormalitie...Read more >
by Gregory Sullivan, M.D.
The investigators will use PET imaging to determine whether the onset of panic disorder is associated with abnormal secretion of the neurotransmitter serotonin in specific brain cell circuits. If so, this improved understanding of panic disorder cou...Read more >
by Ehud Zohary, Ph.D.
Researchers expect that this study will determine whether cortical reorganization occurs in adults who develop macular degeneration and, if so, whether the reorganization facilitates improved vision.While cortical reorganization occurs in congenitall...Read more >
by Geoffrey Aguirre, M.D., Ph.D.
University of Pennsylvania researchers will study what occurs in the awake and sleeping brain while people learn to recognize faces or buildings. The findings should help to explain the role of sleep in this essential learning function, called visua...Read more >
by Daphne Bavelier, Ph.D.
Rochester investigators will combine behavioral tests with brain imaging to understand how people who are deaf acquire reading skills. Their research could lead to improvements in methods for helping deaf people increase their capacity to read. Whil...Read more >
by Sebastian Koch, M.D.
Cognitive decline, such as memory difficulties, may occur in 5-29% of patients after orthopedic surgery. The reasons for this decline are unknown. Recently small fat particles have been detected with ultrasound in the brain circulation of patients...Read more >
by Bradley L. Schlaggar, M.D., Ph.D.
Tourette Syndrome is a rare but socially devastating developmental disorder, in which affected children impulsively have inappropriate actions, such as blurting out swear words. Understanding how to treat developmental conditions requires that we gai...Read more >
by Thomas Liu, Ph.D.
While a decade ago diagnosing Alzheimer’s disease primarily helped a patient and family prepare for the patient’s inevitable cognitive deterioration, today early diagnosis allows for use of promising therapeutic approaches to slow cognitive decline. ...Read more >
by Tamara Hershey, Ph.D.
Juvenile (Type I) diabetes is an autoimmune disease in which the child’s immune system identifies pancreatic cells as foreign” and attacks them, making them less able to rid the body of excess sugar. The newest treatment strategy of intensive therap...Read more >
by Benjamin D. Greenberg, M.D., Ph.D.
Investigators will employ imaging techniques to help assess the efficacy of surgery being used to treat obsessive-compulsive disorder (OCD) in patients who have not responded to previous medical therapies.OCD affects about 2% of the population and pr...Read more >
by Justin Crowley, Ph.D.
Carnegie Mellon scientists will use cellular imaging in laboratory animals to understand how normal brain circuits are formed during development.There are two competing explanations for how brain cells find the right neighbors to connect up with, to ...Read more >
by Brian McCabe, Ph.D.
Researchers will use cellular imaging in the fruit fly and mice to gain a better understanding of the signaling processes that regulate nervous system wiring and how such signaling may go awry in brain diseases such as Amyotrophic Lateral Sclerosis (...Read more >
by Chi-Bin Chien, Ph.D.
Utah investigators will use molecular imaging techniques to view the morphogenesis (structural growth) of the developing eye in zebrafish, to learn how the eye develops normally and how development can go awry in the presence of specific genetic muta...Read more >
by Gülin Öz, Ph.D.
Investigators will increase the sensitivity of non-invasive magnetic resonance spectroscopy (MRS) to improve the study of three Parkinson’s disease processes and how various therapies affect each of these.Parkinson’s disease is characterized by a pro...Read more >
by Binhai Zheng, Ph.D.
These researchers will see, in an animal model of spinal cord injury, whether repeated two-photon cellular imaging can accurately identify injured axons that are regenerating.Lack of scientific tools has hampered efforts to understand the molecular e...Read more >
by Dean B. Andropoulos, M.D.
Foundation funds will support the MRI imaging component of an ongoing controlled clinical study to see if high-dose erythropoietin (EPO) protects against brain injury in infants with congenital heart disease who undergo cardiac bypass surgery. The o...Read more >
by Gabriel S. Dichter, Ph.D.
Researchers will use fMRI imaging in high-functioning adults with autism to explore whether the drug Citalopram reduces their repetitive behaviors by stimulating brain circuits in frontal brain regions. The results may lead to the development of impr...Read more >
by Phillip R. Szeszko, Ph.D.
This study will use diffusion tensor imaging (DTI) of the brain’s white matter (the neural communication cables) in people with schizophrenia and healthy volunteers, along with genetic mapping, to test the hypothesis that variation within specific ge...Read more >
by Song-Hai Shi, Ph.D
Investigators will use two-photon cellular imaging during development in mice with a genetic form of autism to see whether neurons fail to migrate and connect properly in the cerebral cortex. Co-funding for this study will be provided by Autism Spe...Read more >
by Elizabeth A. Kensinger, Ph.D.
This research will use fMRI to examine how changes in the connections between areas of the brain involved in cognition and emotion lead to a more positive rather than negative emotional outlook, and how the direction and strength of those causal conn...Read more >
by Katerina Akassoglou, Ph.D.
The researchers will use two-photon imaging in mice to determine whether blood factors that leak from disrupted blood vessels in the brain and induce immune cells residing in the brain to initiate damaging inflammation.Brain function becomes impaired...Read more >
by Alex Y. Huang, M.D., Ph.D.
Using cellular imaging, researchers will examine how immune destruction of central nervous system (CNS) cells is initiated in the animal model of autoimmune Multiple Sclerosis (MS).Immune system functioning is dependent on the spatial and temporal di...Read more >
by Rachel Katz-Brull, Ph.D.
By strengthening the signal produced by MRS imaging, the researchers will test in animals a potential new non-invasive imaging technique for diagnosing dementia and monitoring treatment effectiveness. Most treatments designed to delay the onset of de...Read more >
by John W. Chen, M.D., Ph.D.
This study in the animal model of multiple sclerosis (MS) will test the ability of a new MRI imaging agent to detect active clinical disease at the earliest stages and monitor changes produced by treatments. The technique also may lead to the develo...Read more >
by Aravinthan D.T. Samuel, Ph.D.
Researchers will use a newly developed nonlinear optical imaging technique in the transparent worm C. elegans to better understand how nerve circuits direct their own repair after traumatic injuries to the adult brain or spinal cord. “Femtosecond la...Read more >
by Mani Pavuluri, M.D., Ph.D.
Researchers will use fMRI to pinpoint areas in the brain’s gray matter (nerve cells) involved in childhood bipolar disorder, and use DTI to identify the white matter areas (the cells’ communication cables) that connect these affected gray matter regi...Read more >
by Natalie Denburg, Ph.D.
This study will use fMRI and PET imaging to determine whether age-related physiological changes in a part of the prefrontal cortex are associated with deficits in reasoning and decision-making that make some older people unusually vulnerable to falli...Read more >
by Jinyuan Zhou, Ph.D.
Researchers will test the ability of a new MRI imaging technique to assess the grade (stage) of brain tumor and to distinguish solid tumor from surrounding edema. Although MRI imaging is the standard of care for assessing deadly brain tumors called...Read more >
by Jeffrey L. Goldberg, M.D., Ph.D.
Researchers will use diffusion tensor imaging (DTI) to determine whether people with the vision disorder amblyopia have structurally or functionally impaired pathways from the eyes to the brain. This could be used to guide future treatment strategies...Read more >
by Ute Frevert, D.V.M., Ph.D.
Researchers will develop a mouse model that produces similar disease processes and clinical symptoms as those that occur in human cerebral malaria, to facilitate imaging studies of the interactions between parasite and immune cells of the host.Cerebr...Read more >
by Timothy Gomez, Ph.D.
Researchers will use “fluorescence imaging biosensors” to visualize biochemical signals within neurons derived from embryonic stem cells to test whether these neurons respond appropriately to molecular guidance cues. The guidance cues to be tested r...Read more >
by Alan P. Jasanoff, Ph.D.
Researchers will develop an MRI imaging sensor to measure real-time signaling by the neurotransmitter dopamine, which is diminished in Parkinson’s disease, as laboratory animals undergo reinforcement (reward) learning.Dopamine signaling pathways in t...Read more >
by Yi Zuo, Ph.D.
The researchers will use cellular imaging in a mouse model of stroke to understand the structural basis and timing of new synapse formation that underlies motor rehabilitation, and will use this information to guide the design of combined training an...Read more >
by Karl A. Kasischke, M.D.
This laboratory animal study will determine whether two-photon imaging can discern how metabolic processes that create energy for brain cells are altered by degenerative diseases and injuries. The brain depends on a steady supply of glucose (sugar)...Read more >
by Richard J. Reimer, M.D.
Researchers will test if their newly developed molecular imaging biosensor, used in combination with electrical measurements, can identify whether excess amounts of the excitatory neurotransmitter glutamate build up in brain tissue in an animal model...Read more >
by Michael Levene, Ph.D.
Yale researchers will test the feasibility of using multiphoton fluorescence imaging in animal model tissue of epilepsy to determine whether this technique can reveal how brain metabolism is slowed in this disease and how this process contributes to ...Read more >
by Beau M. Ances, M.D., Ph.D., M.Sc.
Investigators will determine the feasibility of combining two conventional brain imaging techniques in patients with HIV infection to help reveal how early and acute HIV infection affects the brain and how combination anti-retroviral therapies modify...Read more >
by Pavel Osten, M.D., Ph.D.
This research will employ two cellular imaging techniques to develop a new method to identify and quantify changes in glutamate synaptic transmission that are related to developmental and psychiatric disorders in a mouse model and to assess the effec...Read more >
by Hugo Caldas, Ph.D.
Researchers will use cellular imaging in an animal model of brain tumor to see whether human mesenchymal stem cells—which have been removed from patients’ bone marrow and inserted into the animal—migrate to brain tumor areas to guide surgical removal...Read more >
by Claire Henchcliffe, M.D., Ph.D.
This study will determine if a conventional brain imaging technique can identify abnormally low energy metabolism in brain cells in the substantia nigra in patients with early Parkinson’s disease (PD) and accurately assess the effects of a therapy de...Read more >
by R. Mark Wooten, Ph.D.
Researchers will use multi-photon cellular imaging in a mouse model to determine why immune cells in the skin fail to eliminate the bacterium that causes Lyme disease.Lyme disease can produce debilitating brain encephalitis and meningitis, peripheral...Read more >
by John S Oghalai, M.D.
To develop an objective measure of auditory perception, researchers will use conventional near-infrared spectroscopy (NIRS) imaging in deaf children that are learning to hear through a cochlear implant. This technique has the promise of guiding coch...Read more >
by Maria L. Escolar, M.D., M.S.
This study will assess the feasibility of using conventional diffusion tensor imaging (DTI) of the brain’s white matter in newborns to make treatment decisions concerning those who are at risk for developing the severe and rapidly progressive form of...Read more >
by Jack W. Tsao, M.D., D.Phil.
The investigators will use conventional brain fMRI imaging in servicemen and women who undergo mirror therapy to reduce phantom limb pain from their amputated leg, to determine how this therapy reduces the pain and remodels cortical organization in t...Read more >
by Jeffrey M. Burns, M.D.
Investigators will test the effects of insulin administered through a nasal spray to enhance memory function in patients with early stage Alzheimer’s disease (AD), and they will use conventional brain functional MRI (fMRI) and Arterial Spin Labeling ...Read more >
by Erik W. Dent, Ph.D.
University of Wisconsin investigators will use cellular imaging in laboratory cultures of neurons to explore how regulation of certain neuronal structures may affect brain plasticity,” the development of new neural network connections in the brain. ...Read more >
by Alison Adcock, M.D.
Investigators will perform fMRI analyses of adults engaged in reward-motivated memory tasks to test the hypothesis that learning can be facilitated by activation of the brain’s dopamine-producing nerve cells.The ease with which people learn new infor...Read more >
by Andrew Dunn, Ph.D.
Investigators will use cellular imaging in an animal model of stroke to quantify decreases in brain oxygenation that occur during stroke, and to assess the therapeutic potential of providing oxygen following the stroke to protect nearby brain tissues...Read more >
by Andrew Feigin, M.D.
Investigators will study eight Parkinson’s disease patients who are undergoing treatment with deep brain stimulation of the peduculopontine nucleus and ask if PET (positron emission tomography) imaging can be used to predict which patients benefit fr...Read more >
by Kate Dimond Fitzgerald, M.D.
Investigators will use functional imaging of young patients with obsessive-compulsive disorder to ask if the brain’s error-processing circuits develop abnormally in this disorder.Obsessive-compulsive disorder (OCD) is a common and disabling psychiatr...Read more >
by Michael Greicius, M.D., M.P.H.
Investigators will use a new method of fMRI analysis to study depressed patients undergoing treatment with an antidepressant medication and ask whether resting state network activity can be used to predict which patients will benefit from the medicat...Read more >
by Zezong Gu, M.D., Ph.D.
Investigators will use a mouse stroke model to develop a new molecular imaging technique for monitoring the activity of enzymes that contribute to blood vessel leakage and nerve cell death following stroke.The devastating effects of stroke on the bra...Read more >
by Mirjana Maletic-Savatic, Ph.D.
Investigators will use H-MRS imaging to determine whether infants born extremely prematurely have an abnormally low density of neural progenitor stem cells in the brain’s hippocampus and whether this low density correlates with infants’ long-term cog...Read more >
by John R. Ohlfest, Ph.D.
The investigators will use cellular imaging techniques in a new animal model of lethal brain tumor to determine whether increasing the quantities of a specific type of immune cell in the brain is associated with improved therapeutic outcomes.Glioblas...Read more >
by Erik Shapiro, Ph.D.
Yale researchers will characterize the roles of three types of immune cells involved in the inflammatory response to ischemic stroke, using cellular imaging in an animal stroke model. They then will try to block this immune response to limit damage ...Read more >
by Scott H. Soderling, Ph.D.
Investigators will combine molecular imaging with genetics research to determine how a specific gene mutation leads to abnormal brain cell communication in a mouse model of Fragile X syndrome, the most common inherited form of mental retardation. Fra...Read more >
by J. Paul Taylor, M.D., Ph.D.
These investigators will develop a cellular imaging technique in fruit fly models of three degenerative brain disorders, including Parkinson’s disease, to visualize whether an impaired ability to eliminate mis-folded brain proteins initiates brain ce...Read more >
by Elizabeth Wilde, Ph.D.
The investigators will study traumatic brain injury patients using advanced imaging methods that reveal white matter damage and will assess the efficacy of hypothermia in preventing neurological damage in these patients.Traumatic brain injury (TBI) i...Read more >
by Max Wintermark, M.D.
This study will employ computer assisted tomography (CT) scanning of patients with carotid atherosclerotic disease to see if certain abnormal features of the carotid artery wall can be used to predict stroke risk in these patients. Carotid atheroscle...Read more >
by Aniruddha Das, Ph.D.
Investigators will use several imaging and electrical recording techniques to determine whether BOLD fMRI imaging in laboratory monkeys, and in healthy human study participants, measures not only signals from brain cells activated by repeated visual ...Read more >
by Bonnie Nagel, Ph.D.
Oregon Health Sciences University School of Medicine, Bonnie Nagel, Ph.D. (New investigator)
$200,000 payable over three years
Imaging the teen brain to understand emotional development and vulnerability to mood disordersBrain regions involved in ...Read more >
by Alexandre F. DaSilva, DDS, DMedSc
Researchers will use PET and MRI imaging in people who get migraine headaches and in healthy volunteers to identify factors that may be correlated with the severity of migraine attacks. Migraine is a chronic disorder characterized by sudden attacks ...Read more >
by Eicke Latz, M.D., Ph.D.
Investigators will use molecular FRET imaging in a mouse model of dementia to gain a better understanding of inflammatory and toxic processes involved in Alzheimer’s disease.Alzheimer’s disease is characterized by senile plaques that consist of amylo...Read more >
by Keith A. Schneider, Ph.D.
Researchers will use a new functional magnetic resonance imaging (fMRI) technique to explore whether people with dyslexia, a learning disability, have a visual processing impairment in a specific brain region that impedes their reading abilities.Dysl...Read more >
by Michael J. Levene, Ph.D.
Yale researchers will use cellular imaging techniques in brain tissues of epilepsy patients, which have been surgically removed to treat medication-resistant seizures, to determine the cellular cause of slowed brain metabolism in epilepsy.Epilepsy se...Read more >
by Michelle Hampson, Ph.D
Current treatments for mental disorders are limited. Many individuals do not respond well to the available drugs or behavioral therapies. In addition, those who do respond well to drugs often experience unpleasant side effects. In more severe case...Read more >
by Owen Carmichael, Ph.D.
Investigators will test a new computational method for analyzing MRI images of sub-regions of the brain’s hippocampus in Alzheimer’s disease, to determine whether this method can detect signs of the disease prior to cognitive symptoms and whether it ...Read more >
by Richard E. Harris, Ph.D.
Researchers will use H-MRS imaging in patients with fibromyalgia to determine whether reduction of the excitatory neurotransmitter glutamate in the insula (a specific area of the brain) is associated with decreased sensations of pain and related mood...Read more >
by Thomas Biederer, Ph.D.
Investigators will use cellular imaging techniques to examine the changes that occur at the molecular level at the synapse, the junction between two brain cells, when the cells communicate to facilitate learning. Brain cells communicate with one ano...Read more >
by Thorsten R. Mempel, Ph.D.
This study will use multiphoton intravital microscopy in a mouse brain tumor model to understand how these tumors evade the immune system.Research indicates that adaptive immune cells, called cytotoxic T lymphocytes (CTLs), initially recognize and at...Read more >
by Xincheng Yao, Ph.D.
Researchers will develop an optical imaging technique designed to detect cellular signs of vision diseases early, when they can be treated most effectively, and test this approach in animal models.Several serious eye diseases can lead to vision loss ...Read more >
by Thomas A. Blanpied, Ph.D.
This study will explore how beta amyloid, a protein heavily implicated in Alzheimer’s disease, may disrupt synaptic communication in the brain.Neurons communicate with one another at the synapse, the junction between them. Brain synapses have two pro...Read more >
by Ramin Parsey, M.D., Ph.D.
Researchers will use PET imaging to determine how lithium acts on the transmitter serotonin to provide therapeutic benefit in patients with bipolar disease.Lithium has been used for more than two decades to treat bipolar disorder, primarily by preven...Read more >
by Jack B. Nitschke, Ph.D.
This study will use three types of imaging to identify specific brain alterations that occur in soldiers with post-traumatic stress disorder (PTSD) and to evaluate the effects of treatment on these changed brain structures and functions.Studies of co...Read more >
by Keith Josephs, MST, M.D.
This research aims to identify structural brain changes that occur over the course of progressive supranuclear palsy (PSP) and relate explicit brain changes to the onset of specific signs and symptoms of the disease.PSP is a devastating neurodegenera...Read more >
by Jason Maclean, Ph.D.
Researchers will explore how information is processed and memories are stored at the level of brain circuits—neuronal networks—as viewed through two-photon imaging of mouse brain.Newly developed cellular imaging technologies can reveal actions of ind...Read more >
by Matthew B. Dalva, Ph.D.
Researchers will examine the dynamics of intracellular signaling that give rise to the formation of synapses, junctions connecting one brain cell to another to facilitate communication and plasticity.One key component in the development of synapses b...Read more >
by Andrew Lassman, M.D.
This study will help to determine the validity and reliability of a new PET imaging tracer for assessing deadly brain tumor progression and the efficacy of anti-tumor agents in killing the tumor or slowing or preventing its growth.Malignant brain tum...Read more >
by Bo Li, Ph.D.
Investigators will use two-photon molecular imaging in a mouse model of depression to develop direct evidence of cellular changes that cause depression and whether pharmaceutical agents can reverse these changes.
Three types of anti-depressants a...Read more >
by Li Min Chen, M.D., Ph.D.
Investigators will determine whether leading edge MRI imaging techniques in a non-human primate model of spinal cord injury can be used to predict the extent of subsequent functional recovery.About one-half of all spinal cord injuries result in quadr...Read more >
by Arie Kaffman, M.D., Ph.D.
Investigators will use cellular imaging in mice to help identify the molecular events involved in early life stress that may modify complex behaviors, such as anxiety, impulse control and memory, later in life. The animal studies are expected to have...Read more >
by Randy Bruno, Ph.D.
Researchers will use two-photon cellular imaging in mice as an initial step in determining whether a specific brain network facilitates attention and, if disordered, fails to do so in human disorders such as Attention Deficit Hyperactivity Disorder (...Read more >
by Kristina Visscher, Ph.D.
Investigators will determine how macular degeneration modifies visual activity in the brain, and how this activity is further modified by training designed to increase the speed of patients’ cognitive processing. About two million older adults have ...Read more >
by Hak Soo Choi, Ph.D.
Investigators from Harvard, collaborating with scientists at Dana-Farber Cancer Institute, will develop new contrast agents for image-guided brain tumor surgery in an animal model of induction glioma. If successful, this research will be immediately ...Read more >
by Michael James Potchen, M.D.
This MRI study in sub-Saharan African children with cerebral malaria will seek to validate initial evidence about how the disease damages the brain and produces severe cognitive and motor disabilities.Nine million children in sub-Saharan Africa devel...Read more >
by Liane Young, Ph.D.
This study will use fMRI and behavioral measures to determine whether highly functioning adults with autism spectrum disorders (ASD) have deficits in their abilities to reason about other people’s mental states (beliefs and intentions) and to identif...Read more >
by Amit Etkin, M.D., Ph.D.
This study in depressed patients will examine how depression may be produced by malfunctioning interactions of two neural networks and how a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) intervenes to improve outco...Read more >
by Michael M. Minzenberg, M.D.
Investigators will use fMRI to assess the extent to which two commonly used antipsychotic drugs interfere with cognitive control functions in patients with schizophrenia. They also will determine how these drugs may limit the effectiveness of medicat...Read more >
by Moritz Kircher, M.D.,Ph.D.
This study will validate a new MRI imaging technique in an animal model of brain tumor that could enable surgeons to precisely remove all tumor cells to extend survival and possibly save lives. Patients with deadly brain tumors (glioma) rarel...Read more >
by Isabella Rosso, Ph.D.
Investigators will use an advanced method of spectroscopy imaging they developed to directly measure levels of the inhibitory neurotransmitter GABA in patients with post-traumatic stress disorder (PTSD) and determine whether low GABA levels correlate...Read more >
by Vincent A. Magnotta, Ph.D.
In this study, investigators will use magnetic resonance spectroscopy (MRS) imaging to explore whether panic disorder could result from abnormally low levels of acidity (pH) in the brain.The brain maintains a balance between acidity and alkalinity (w...Read more >
by Teresa R. Franklin, Ph.D.
Researchers will use a newly developed SPECT imaging technique to explore whether a specific genetic factor helps to explain why some people have an especially hard time quitting smoking. Annually, about 40 percent of the nation’s 36 mil...Read more >
by Glenn Walter, Ph.D.
Researchers will develop and validate a new MRI imaging technique to visualize how neural degeneration actually occurs over time in a single neural circuit in Parkinson’s disease. Then they will use this MRI imaging technique to validate its potentia...Read more >
by Adam Carter, Ph.D.
This cellular imaging study in normal mice and in those with Parkinson’s disease will help identify how electrochemical communication between brain cells normally occurs, and how this communication is altered in Parkinson’s disease.Parkinson’s diseas...Read more >
by Beth Stevens, Ph.D.
Investigators will use cellular imaging in mice to study how innate immune system processes prune inactive brain synapses during development, and also how they eliminate synapses in neurodegenerative diseases in a mouse model of glaucoma.During devel...Read more >
by Lisa Aziz-Zadeh, Ph.D.
Investigators will use MRI and fMRI imaging to examine whether, and how best, the mirror neuron system can be activated following stroke to optimally tailor stroke rehabilitation for individual patients.The human mirror neuron system (MNS) refers to ...Read more >
by Irina Esterlis, Ph.D.
Investigators will use PET and MRS (magnetic resonance spectroscopy) imaging in patients with depression and healthy volunteers to determine the role that the brain’s glutamate (excitatory) neurotransmitter system plays in depression and its associat...Read more >
by Prakash Kara, Ph.D.
Using cellular imaging in the mouse model of Alzheimer’s disease and in normal mice, investigators ultimately plan to determine how synapses (the junction between two brain cells) are normally activated, and the number of synapses that must be lost ...Read more >
by Moritz Kircher, M.D.,Ph.D.
This study will validate a new MRI imaging technique in an animal model of brain tumor that could enable surgeons to precisely remove all tumor cells to extend survival and possibly save lives. Patients with deadly brain tumors (glioma) rarel...Read more >
by Emad N. Eskandar, M.D.
This neurosurgical research team will explore, at the neuronal level, how two brain networks normally drive the balance between safe and risky decision-making behaviors, and use the findings to design deep brain stimulation (DBS) strategies for modif...Read more >
by Michael L. Lipton, M.D., Ph.D.
Investigators will use diffusion tensor imaging (DTI), cognitive testing and gene studies to determine levels of sub-concussive head injury from soccer “heading” that increase the risk for adverse brain and cognitive functioning, and identify factors...Read more >
by Michelle Bradbury, M.D., Ph.D.
Researchers will undertake studies in cancer patients and animal models to determine whether a PET imaging agent effectively carries and delivers a drug treatment for fighting metastatic cancers in the brain.
The two most common metastatic cancers i...Read more >
by Christopher Smyser, M.D.
Investigators will determine whether a new type of imaging, Functional Connectivity MRI, can effectively identify pre-term infants with injuries to the brain’s white matter (communication cables) that place them at greatest risk of developing cerebra...Read more >
by Jordan Jacobelli, Ph.D
Investigators will use real-time fluorescent multi-photon microscopy imaging in a mouse model of multiple sclerosis to define the routes that autoimmune T cells use to enter the brain and spinal cord and attack the myelin sheaths that insulate nerve...Read more >
by Francis E. Lotrich, M.D., Ph.D.
Investigators will use BOLD fMRI and “arterial spin labeling” to explore how neural transmission of serotonin is altered in people who develop major depressive disorder in the presence of inflammation, and to identify factors that may determine pre-e...Read more >
by Chris Abbott, M.D., M.S.
This study will employ resting state fMRI to determine how electroconvulsive therapy exerts a therapeutic effect in patients with major depressive disorder, and to identify biomarkers that predict which patients are likely to relapse following ECT tr...Read more >
by Xin Jin, Ph.D.
This cellular imaging study in the Parkinson’s disease animal model will explore which of two hypothesized neural signaling problems is responsible for loss of voluntary motor control. People with Parkinson’s disease (PD) develop a characteristic gai...Read more >
by Peter de Blank, M.D., MSCE
This first phase of a planned two-phase study will determine whether it is feasible to use two imaging techniques in very young children with optic glioma. If feasible, the investigators propose a second phase to determine if the combined imaging can...Read more >
by Jonathan Peelle, Ph.D.
This study will investigate how common age-related hearing loss changes brain structure and function, and what consequences these neurobiological effects have on understanding and remembering speech.
Behind only arthritis and hypertension, hearing l...Read more >
by Jong Yoon, M.D.
This study will examine whether high dopamine levels, as measured by high resolution fMRI, correlates with the onset of psychosis in schizophrenia and can serve as a diagnostic and therapeutic biomarker.
The prognosis for schizophrenia is poor. No...Read more >
by Andy Shih, Ph.D.
Through studies in mice, researchers will seek to improve MRI detection of tiny blockages in the brain’s small blood vessels that can lead to vascular dementia. Their findings may help clinicians identify at-risk patients and implement early preventi...Read more >
by Nim Tottenham, Ph.D.
Investigators will correlate MRI brain
imaging with studies of stress-related gene alterations and anxiety behaviors
to explore how early life stress may influence brain development and then
mental health years later.Prior animal and human studie...Read more >
by Ragy Girgis, M.D.
This research is designed to
determine whether MRS imaging (Magnetic Resonance Spectroscopy) can assess the
effects of experimental therapies in increasing glutamate levels to treat
schizophrenia. Currently schizophrenia is
treated with antipsyc...Read more >
by Susan Schwab, Ph.D.
Investigators anticipate that
cellular imaging techniques in a multiple sclerosis mouse model will enable
them to identify the signaling that drives immune cell infiltration and
inflammation in autoimmune multiple sclerosis (MS) and assess whether...Read more >
by Mikhail Shapiro, Ph.D.
The ultimate goal of this
planned two-phase study is to use a novel MRI imaging agent to show, in living
laboratory mice, how brain inflammation occurs and damages cells following
brain injury. Phase I will establish the imaging approach’s feasibi...Read more >
by Vikram Chib, Ph.D.
will undertake Phase I of a planned two-phase study to ultimately determine
whether a non-invasive brain stimulation technique helps schizophrenia patients
learn from positive rewards and reduce the “negative” symptoms that
characteri...Read more >
by Sarkis K. Mazmanian, Ph.D.
The long vagal nerve transmits signals
between the brain and the gut. The evolutionally ancient gut microbial systemis
made up of 100 trillion bacterial
cellscomprised of more than 1,000
species that live in symbiosis with
thehuman and non-huma...Read more >
by Daniel Licht, M.D.
will test the validity of using an optical non-invasive imaging technique,
which continuously monitor cerebral blood flow and brain oxygenation, for
determining which infants are at greatest risk of developing abnormal cerebral
blo...Read more >