by Stanley B. Prusiner, M.D.
Chronic traumatic encephalopathy (CTE) is a progressive degenerative brain disease that results from repetitive “closed” head trauma and produces symptoms that range from problems with attention, concentration, disorientation, and depressio...Read more >
by Dr. Michael Rafii
study of adults
with Down’s syndrome, who have a high probability of
developing mild cognitive impairment that eventually progresses
dementia superimposed on the existing intellectual
disability, may identify biomarker...Read more >
by Dr. Martin M. Monti
Investigators will conduct the first clinical evaluation of the effects of using non-invasive Low Intensity Focused Ultrasound Pulsations to restore consciousness in a small number of severely head-injured adults. Few disorders ar...Read more >
by Diego Pizzagalli, Ph.D. and Randy Auerbach, Ph.D.
Investigators will use psychological testing and imaging in teenage girls whose mothers have major depressive disorder to determine whether specific neurological factors predict which of the adolescents will similarly develop depression.
...Read more >
by Sameer Sheth
Neurosurgical researchers will explore how a specific brain network functions as people make decisions. We are constantly making decisions. Often we make them rapidly with nearly imperceptible effort. Other decisions require ...Read more >
by Samuel Cheshier, M.D., Ph.D.
neurosurgeon and neuroradiologist team will determine whether a new
non-invasive MRI imaging technique can reveal innate immune cells’ presence in
deadly brain tumors in children and adults, and can be used to assess responses
to ...Read more >
by Rose Du, M.D., Ph.D.
a two-phase exploration, neurosurgeons will seek to identify factors that may
predispose certain patients with ruptured brain aneurysms to experience
complications leading to poor neurological outcomes. Doing so may lead to new
approaches to ...Read more >
by Drs. Wade H. Berrettini and Kyle Kampman
who are part of a University of Pennsylvania expert group studying drug
addiction will conduct a Phase II clinical trial in 40 adult cocaine users of
an experimental drug that may block cocaine’s action in the brain. If the drug
pr...Read more >
by Craig Stark, Ph.D.
Intriguing research in young
adults suggests that their memory can be improved by the act of exploring richly
stimulating environments in 3-D video games. Importantly, the memory
improvements seen so far are not confined to simply playing the same...Read more >
by Bruce McEwen, Ph.D., and Ana Pereira, M.D.
will expand their Dana-supported pilot clinical trial to gain an initial
indication of whether the drug riluzole can improve functioning in adults with age-related
cognitive problems and those with mild cognitive impairment (MCI). Conc...Read more >
by Guy McKhann, M.D.
For the first time, researchers may be
able to define the interrelated functional and structural brain changes that
evolve over time in cognitively healthy adults who eventually develop
Alzheimer’s disease (AD). Identifying the earliest brain sign...Read more >
by Professor Marin Rossor and Professor Sir Mark Pepys
a small number of patients with mild Alzheimer’s disease, investigators will
test the effects on synaptic transmission of an experimental drug that depletes
“serum amyloid P component,” a potential new target for treating Therapeutic approaches...Read more >