Current Grantees

Determinants of Delayed Ischemic Neurological Deficits and Infarction after Aneurysmal Subarachnoid Hemorrhage

by Rose Du, M.D., Ph.D.

 In a two-phase exploration, neurosurgeons will seek to identify factors that may predispose certain patients with ruptured brain aneurysms to experience complications leading to poor neurological outcomes. Doing so may lead to new approaches to ...
Read more >

Enrichment of neurogenesis in the hippocampus via the environment

by Craig Stark, Ph.D.

Intriguing research in young adults suggests that their memory can be improved by the act of exploring richly stimulating environments in 3-D video games. Importantly, the memory improvements seen so far are not confined to simply playing the same...
Read more >

Understanding the susceptibility of glutamatergic neural circuits to Alzheimer's disease: clinical and basic studies

by Bruce McEwen, Ph.D., and Ana Pereira, M.D.

Researchers will expand their Dana-supported pilot clinical trial to gain an initial indication of whether the drug riluzole can improve functioning in adults with age-related cognitive problems and those with mild cognitive impairment (MCI). Conc...
Read more >

Will non-invasive vagus nerve stimulation help improve upper limb function following stroke?

by Drs. Judith Schaechter & Vitaly Napadow

A randomized controlled trial of post-acute stroke patients is planned to provide preliminary evidence that non-invasive vagus nerve stimulation, combined with arm motor training, improves motor function of patients’ affected arm and hand.  Inves...
Read more >

Can median nerve stimulation restore consciousness following subarachnoid hemorrhage?

by Jan Claassen, M.D., Ph.D.

This study in patients who have lost consciousness following a subarachnoid hemorrhage will lay the foundation for undertaking larger-scale clinical trials to see whether stimulating patients’ median nerve helps them to regain consciousness. The ...
Read more >

Exploring a potential new therapy for fatal Canavan disease 

by David Pleasure, M.D.

Investigators will test in a mouse model a new approach to treating the fatal inherited condition in infants and children called ‘Canavan” disease. If promising, the research is anticipated to lead to human clinical testing of this first potential th...
Read more >