Current Grantees

Study of highly prevalent Alzheimer's disease in Down's syndrome adults may yield AD biomarkers

by Dr. Michael Rafii

    This longitudinal study of adults with Down’s syndrome, who have a high probability of developing mild cognitive impairment that eventually progresses to dementia superimposed on the existing intellectual disability, may identify biomarker...
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Filling the treatment gap: Ultrasonic thalamic stimulation in disorders of consciousness following severe brain injury

by Dr. Martin M. Monti

         Investigators will conduct the first clinical evaluation of the effects of using non-invasive Low Intensity Focused Ultrasound Pulsations to restore consciousness in a small number of severely head-injured adults.           Few disorders ar...
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Determinants of Delayed Ischemic Neurological Deficits and Infarction after Aneurysmal Subarachnoid Hemorrhage

by Rose Du, M.D., Ph.D.

 In a two-phase exploration, neurosurgeons will seek to identify factors that may predispose certain patients with ruptured brain aneurysms to experience complications leading to poor neurological outcomes. Doing so may lead to new approaches to ...
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A Novel Compound for Cocaine Addiction

by Drs. Wade H. Berrettini and Kyle Kampman

 Investigators who are part of a University of Pennsylvania expert group studying drug addiction will conduct a Phase II clinical trial in 40 adult cocaine users of an experimental drug that may block cocaine’s action in the brain. If the drug pr...
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Enrichment of neurogenesis in the hippocampus via the environment

by Craig Stark, Ph.D.

Intriguing research in young adults suggests that their memory can be improved by the act of exploring richly stimulating environments in 3-D video games. Importantly, the memory improvements seen so far are not confined to simply playing the same...
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Understanding the susceptibility of glutamatergic neural circuits to Alzheimer's disease: clinical and basic studies

by Bruce McEwen, Ph.D., and Ana Pereira, M.D.

Researchers will expand their Dana-supported pilot clinical trial to gain an initial indication of whether the drug riluzole can improve functioning in adults with age-related cognitive problems and those with mild cognitive impairment (MCI). Conc...
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Identifying pre-symptomatic Alzheimer’s brain changes to facilitate early treatment

by Guy McKhann, M.D.

For the first time, researchers may be able to define the interrelated functional and structural brain changes that evolve over time in cognitively healthy adults who eventually develop Alzheimer’s disease (AD). Identifying the earliest brain sign...
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Serum amyloid P component (SAP) in Alzheimer's

by Professor Marin Rossor and Professor Sir Mark Pepys

In a small number of patients with mild Alzheimer’s disease, investigators will test the effects on synaptic transmission of an experimental drug that depletes “serum amyloid P component,” a potential new target for treating Therapeutic approaches...
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Will non-invasive vagus nerve stimulation help improve upper limb function following stroke?

by Drs. Judith Schaechter & Vitaly Napadow

A randomized controlled trial of post-acute stroke patients is planned to provide preliminary evidence that non-invasive vagus nerve stimulation, combined with arm motor training, improves motor function of patients’ affected arm and hand.  Inves...
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Can median nerve stimulation restore consciousness following subarachnoid hemorrhage?

by Jan Claassen, M.D., Ph.D.

This study in patients who have lost consciousness following a subarachnoid hemorrhage will lay the foundation for undertaking larger-scale clinical trials to see whether stimulating patients’ median nerve helps them to regain consciousness. The ...
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