When is using medication to lessen psychological pain an ethically defensible choice? © Getty Images/Photodisc
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"Cosmetic Neurology" and the Problem of Pain

By Anjan Chatterjee, M.D.
July 30, 2007

Few people would argue against treating the traumatic psychological effects of war or violence. But what about taking a drug to lessen the pain of our common daily struggles, such as the end of a relationship or anxiety about one’s job? Is this a “cosmetic” enhancement of human life, even a danger to character, or is it an ethical choice? For guidance, the author looks to the history of treating physical pain and argues that, despite growing knowledge of the biological basis for psychological pain, many find it hard to find a consistent principled position when it comes down to specific instances of alleviating human suffering.

We are all familiar with —and many are troubled by—athletes who use medications, legal or otherwise, to enhance their performance. This practice is an early indication of a much larger trend. As neuroscience advances, we are getting better at treating cognitive and emotional disorders, and we are also learning how to improve cognition and modify emotions in basically normal, healthy people—for example, by increasing alertness or lessening fear. I have coined the term “cosmetic neurology” for this practice.1 

Cosmetic neurology raises four major ethical concerns. First is a concern about safety. We weigh the potential risks and side effects of a new medication for a disease against the potential benefits. In health, are any risks worth taking? For example, musicians often use beta-blockers to dampen tremors and anxiety associated with public performance. Occasionally, however, beta-blockers are associated with a life-threatening anaphylactic (allergic) reaction in which a it’s not always clear that an individual would be better off without the drug. What some might see as a dubious or even dangerous enhancement, others believe is an ethical means of relieving suffering. person’s blood pressure drops and breathing stops. Is the better concert worth this risk? Second is a concern about distributive justice: If cosmetic neurology succeeds in making people smarter and happier, will these enhancements be available disproportionately to the affluent? Third is a concern about coercion. Will healthy people be or feel forced to take such medications, either because it would serve a greater good (for example, airline pilots being required to take a drug to increase alertness if that made flying safer) or because of competitive pressures?

Finally—and this is the focus of this article—ethicists and others have expressed a subtle but deep concern about ways in which manipulating our emotional lives might erode character, both individually and communally. This was a fundamental concern raised by the Presidential Commission on Bioethics and highlighted in its 2003 report, Beyond Therapy.2 If, as many religions and philosophies argue, struggle and even pain are important to the development of character, does the use of pharmacological interventions to ameliorate our struggles undermine this essential process?

The widespread practice of cosmetic neurology seems inevitable, and resolving this concern will not be easy. Many people share an underlying discomfort with how things might play out. But when we consider specific instances of using a medication to affect emotion and treat psychological pain, it’s not always clear that an individual would be better off without the drug. What some might see as a dubious or even dangerous enhancement, others believe is an ethical means of relieving suffering.

In my view, the history of the treatment of physical pain, including “natural” pain, anticipates the treatment of psychological pain. Similar tensions are certainly at play. This claim is predictive, not prescriptive—I am neither advocating nor decrying the use of cosmetic neurology. I am, instead, pointing out how deeply difficult it is for anyone, ethicists included, to adopt a consistently principled position on the problem of pain.

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Comments

Unequal Distribution of Pain

William Harjo Lone Fight

1/8/2009 7:42:13 PM

When does "cosmetic neurology" become reconstructive? If we use the metaphor of plastic surgery, it seems that many are graced with very few "wounds beneath the flesh" and others, particularly "subordinated groups," carry the pain of many.

Perhaps what Anjan Chatterjee was hinting at without directly addressing is pain without context or meaning. Pain is a part of many Native American ceremonies in which its meaning is explicit and supported by consensus. In a fragmented world, psychological pain is often without meaning. Psychological pain, we would presume, is intended to signify a need for change. "Pain means that something is wrong." But what if the cause is unaddressable or global?

Growing up as a child with the fear that every thunderstorm was the beginning of a thermonuclear war induced signficant pain. Perhaps that pain shaped me into a more moral human being. Perhaps it merely increased the suffering of a child. As has often been said, "if pain builds character, when do we have enough character for the day?"

There has never been equality in suffering. Some are forged in fire and some are melted. Not being a gambler by nature and having seen more melting than forging, I see the experience of psychological pain as a choice we adults may make. The complexity arises when it comes to children. How much pain do we allow? My answer would be that pain be prescribed, if you will, based on context and interpretation. We do need to learn what type and conditions of pain strengthen and what do not. There is research on the subject.

Leilani Doty, PhD, Director, University of Florida Cognitive & Memory Disorder Clinics

Leilani Doty, PhD

8/31/2007 1:23:58 PM

Anjan Chatterjee truly is a renaissance behavioral neurologist,a gifted eclectic thinker and wordsmith. As he discusses the contructs of cosmetic neurology and treatments for pain and other multi-level discomforts of the patient, where does he insert the benefits of the natural analgesics and natural mood modifiers?

Of course, I am speaking about the endorphin releases that occur during the unmedicated child birthings (that occur without medical complications and aggressive medical interventions). Of course, I am talking about physical exercise that releases endorphins and other ameliorative chemicals that alleviate physical, emotional and spiritual pain. Of course, I am talking about positive interactions in relationships, psychotherapy and other therapies such as positive reframing that transform psychological, spiritual and related physical pain. Of course, I am talking about the transformation of writer's stress, very emotionally painful, to the exhilaration of seeing the final manuscript in a refereed (or other)publication, such as this article.

Where do these natural "treatments" fit in cosmetic neurology?

Daily reasons for pause

Sean C. Orr

8/16/2007 10:41:37 AM

Dr. Chatterjee crystalizes a complex topic skillfully. As a neurologist, I encounter situations daily that, in this contextual framework, could give me pause. As a physician with the ability to judge and discern, I guide my patients on the basis of striving for the greatest good, or the best outcome, for that patient and for society. At times, that includes witholding certain medications that would temporarily alleviate pain, with the knowledge that a greater good is served in the long run. At times, that also includes administering medications in an "off-label" fashion, knowing that quality of life is enhanced without incurring a net negative effect for that patient or society at large. This is the essence of individualization of care.

To some extent, it seems a bit trivial to argue whether a relatively small number of people will abuse cognition enhancing medications when so many are already abusing more toxic substances that alter conscious perception. From a certain point of view, one might easily argue that alcohol is used to alleviate pain, to dampen anxiety, to augment self esteem and to stimulate creativity. Perhaps "healthier" alternatives will emerge that will replace alcohol, reducing its burden on our healthcare and justice systems.

I am curious, Dr. Chatterjee:  Do you foresee a day in which Cosmetic Neurology would extend to genetic therapy and stem cell therapy, in an attempt to reengineer pain thresholds and cognitive capacities? If so, do you also foresee a day when wetware/neurocybernetic interfaces may also fall under the purvue of the Cosmetic Neurologist? Or would you advocate that other subspecialties of Neurology adopt these modalities instead? Does this smack of eugenics, or can our emerging neuroeconomy justify these therapies solely on the basis of improved health?

Dr.

Norman Holland

8/8/2007 10:38:46 AM

I admired Dr. Chatterjee's balanced essay on "cosmetic neurology," particularly in view of the widespread belief that pain builds character. It is as old as Aeschylus. I am curious: Have we in these latter days found evidence that this is true?

References

1. Chatterjee A. Cosmetic neurology: The controversy over enhancing movement, mentation, and mood. Neurology. 2004;63:968–974.

2. President's Council on Bioethics. Beyond Therapy: Biotechnology and the Pursuit of Happiness 2003.

3. LeDoux J. Emotion circuits in the brain. Annual Review of Neuroscience. 2000;23:155–184.

4.  McGaugh JL. The amygdala modulates the consolidation of memories of emotional experiences. Annual Review of Neurosciences.  2004;27:1-28.

5. Caton D. What a blessing she had chloroform: the medical and social response to the pain of childbirth from 1800 to the present. New Haven, Connecticut: Yale University Press, 1999.

6. Price D. Psychological and neural mechanisms of the affective dimension of pain. Science. 2000;288:1769–1772.