Intraoperative optical recording of intrinsic signals is a more accurate technique for mapping human neocortical epilepsy than current electrophysiological methods, which have inherent limitations in spatial localization. Surgical resections based on this novel optical mapping technique will lead to improved outcome in the treatment of human epilepsy.
1. To optimize the intraoperative application of intrinsic signal imaging.
2. To optically map human neocortical epilepsy.
Patients undergoing resective surgery for medically intractable neocortical epilepsy will undergo electrocorticography to localize interictal and ictal spike zones. These regions will be imaged with a custom designed camera holder and cortical stabilization equipment using a CCD camera while simultaneously recording the ECoG.