Current Grantees

Riluzone in patients with cognitive disorders

by Bruce McEwen, Ph.D; Ana C. Pereira, M.D.

Goal: Investigators will conduct an initial clinical study of the drug Riluzole in a small number of adults with mild cognitive impairment to see whether it decreases metabolic changes in the brain that may be associated with progression to Alzheimer...
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Translational research on speech and language may lead to improved post-stroke aphasia therapy

by Sheila Blumstein, Ph.D.

This pilot study will explore the potential efficacy of a targeted speech therapy program in improving speech sounds and ultimately communication by patients who developed aphasia as a result of a stroke.   Stroke-induced injuries to the brain can r...
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Identifying Optimal Targets and Stimulation Protocols for the Treatment of Psychiatric Disorders

by Emad Eskandar, M.D.

This neurosurgical research team will explore, at the neuronal level, how two brain networks normally drive the balance between safe and risky decision-making behaviors, and use the findings to design deep brain stimulation (DBS) strategies for modif...
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Real-Time Physiological Visualization of the Comatose Human Brain

by Stephan Mayer, M.D.

Investigators will create the capacity to graphically display real-time brain physiologic changes in comatose patients to guide urgent clinical interventions to prevent further damage.  Continuous multimodal monitoring systems that measure and recor...
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Double Blind Trial of the Safety and Efficacy of GM-CSF Leukine in the Treatment of Alzheiemer's Disease

by Huntington Potter, Ph.D.

Investigators will undertake the second phase of their clinical study to determine in a small number of people with Alzheimer’s disease whether the drug Leukine shows promise in improving patients’ cognitive abilities and arrests brain atrophy. Abou...
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Formation of tau prions in transgenic mice following traumatic brain injury

by Stanley B. Prusiner, M.D.

         Chronic traumatic encephalopathy (CTE) is a progressive degenerative brain disease that results from repetitive “closed” head trauma and produces symptoms that range from problems with attention, concentration, disorientation, and depressio...
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Study of highly prevalent Alzheimer's disease in Down's syndrome adults may yield AD biomarkers

by Dr. Michael Rafii

    This longitudinal study of adults with Down’s syndrome, who have a high probability of developing mild cognitive impairment that eventually progresses to dementia superimposed on the existing intellectual disability, may identify biomarker...
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Filling the treatment gap: Ultrasonic thalamic stimulation in disorders of consciousness following severe brain injury

by Dr. Martin M. Monti

         Investigators will conduct the first clinical evaluation of the effects of using non-invasive Low Intensity Focused Ultrasound Pulsations to restore consciousness in a small number of severely head-injured adults.           Few disorders ar...
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Assessing stroke risk in patients undergoing non-surgical aortic valve replacement

by Guy McKhann, M.D.

    This study will continue an assessment of whether the increased risk of stroke in older patients who undergo a catheter-based rather than surgical replacement of their aortic valve is associated with the technique or with their underlying vas...
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Towards Identification of Neural Predictors of Adolescent Depression: A Multi-Model Neuroimaging Study

by Diego Pizzagalli, Ph.D. and Randy Auerbach, Ph.D.

         Investigators will use psychological testing and imaging in teenage girls whose mothers have major depressive disorder to determine whether specific neurological factors predict which of the adolescents will similarly develop depression.  ...
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Investigating the Physiology of Human Decision-Making

by Sameer Sheth

         Neurosurgical researchers will explore how a specific brain network functions as people make decisions.                We are constantly making decisions. Often we make them rapidly with nearly imperceptible effort. Other decisions require ...
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Nanoparticle-Based MRI for First-In-Man Immune-Therapy Trials in Brain Tumor Patients

by Samuel Cheshier, M.D., Ph.D.

           This neurosurgeon and neuroradiologist team will determine whether a new non-invasive MRI imaging technique can reveal innate immune cells’ presence in deadly brain tumors in children and adults, and can be used to assess responses to ...
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