A Preclinical Risk Marker for Alzheimer’s Disease by Functional MRI
Shi-Jiang Li, Ph.D.
Medical College of Wisconsin , Milwaukee, WI
David Mahoney Neuroimaging Program
November 2001, for 3 years
Shi-Jiang Li, Ph.D.
Associate Professor, Biophysics Research Institute, Medical College of Wisconsin
A newly developed functional MRI (fMRI) index to quantify the abnormality of functional synchrony in the human hippocampus is an early and sensitive biological marker to characterize the preclinical abnormality of Alzheimer's disease (AD).
To develop and validate an early, non-invasive, quantitative marker for the preclinical stage of Alzheimer's disease (risk marker) using fMRI. Such a sensitive marker for AD will have significant advantages in identifying people at risk, facilitating early assessment, and providing effective disease management.
To establish a preclinical marker for Alzheimer's, the researchers will conduct a longitudinal study of subjects with mild cognitive impairment (MCI) to determine who does and does not develop Alzheimer's during a three-year study. At the same time, we will determine the longitudinal change in the COSLOF index in their hippocampus regions. The researchers chose to study MCI subjects because of their high incidence (yearly 12-15%) of Alzheimer's development. At the end of the three-year period, we can look back to determine how well the COSLOF index predicted the preclinical onset of Alzheimer's and distinguished those subjects who were destined to develop Alzheimer's from those who were undergoing normal aging processes.
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