Andrew H. Miller, M.D.
Andrew H. Miller, M.D., the William P. Timmie Professor of Psychiatry and Behavioral Sciences at Emory University School of Medicine in Atlanta, studies brain-immune interactions as they relate to stress and depression. His work focuses on the mechanisms by which cytokines cause depression in humans and nonhuman primates using chronic administration of the innate immune cytokine, interferon-alpha as a model of chronic immune stimulation. Miller has also studied the impact of cytokines on neuroendocrine regulation as well as sleep. Miller and his group have conducted clinical trials examining the efficacy of cytokine antagonists in patients with treatment-resistant depression. In addition to his research work, Miller is the director of Psychiatric Oncology and co-leader of the Cancer Prevention and Control Program at Emory’s Winship Cancer Institute.
Do Cytokines Really Sing the Blues?
Evidence suggests several causes for depression, including traumatic life events, disease, poison, and nutritional deficiencies. Many of these causes are associated with elevated levels of inflammatory biomarkers in the blood, which may in turn lead to inflammatory changes in the brain. Our authors examine what the latest research reveals about the link between inflammation in the brain and depression, and how a better understanding of that link can play a critical first step in the personalization of care.