This fourth annual collection brings together the foremost experts in brain science. Jay Giedd, Michael Posner, Mariale Hardiman, David Kupfer and Paul McHugh present their research – and their take – on such cutting-edge topics as the development of the teen brain, how arts education affects intelligence, the limitations of brain imaging, and how to bring more certainty and flexibility to diagnosis in the next edition of the psychiatric bible, the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).